尿微量白蛋白、尿蛋白肌酐比与肾小球滤过率在糖尿病肾病临床检验中价值分析

Value Analysis of Urinary Microalbumin,Urinary Protein Creatinine Ratio and Glomerular Filtration Rate in Clinical Examination of Diabetes Nephropathy

目的分析糖尿病肾病临床检验中尿微量白蛋白、尿蛋白肌酐比与肾小球滤过率的诊断效能。方法回顾性选取2021年1月—2023年12月于厦门医学院附属第二医院检验科行临床检验的106例2型糖尿病患者的临床资料,根据是否确诊糖尿病肾病将上述划分为对照组(46例)和确诊组(60例)。分别对两组尿微量白蛋白、尿蛋白肌酐比与肾小球滤过率水平进行分析,同时通过受试者操作特征(receiver operating characteris⁃tic curve,ROC)曲线分析不同指标单一检测以及联合检测的诊断效能。结果确诊组尿微量白蛋白及尿蛋白肌酐比均高于对照组,肾小球滤过率低于对照组,差异有统计学意义(P均<0.05)。ROC曲线分析结果显示,联合检验曲线下面积为0.845,灵敏度为73.3%、特异度为95.7%均高于其他单一检测,差异有统计学意义(P均<0.05)。结论单一指标在糖尿病肾病临床检验中具有一定局限性,联合检验可显著提高诊断效能,具有临床价值。

Objective The diagnostic efficacy of urinary microalbumin,urinary protein creatinine ratio and glomerular filtration rate in clinical examination of diabetes nephropathy was analyzed.Methods The clinical data of 106 patients with type 2 diabetes mellitus who underwent clinical examination in the clinical Laboratory Department of the Second Affiliated Hospital of Xiamen Medical College from January 2021 to December 2023 were retrospectively selected.Ac-cording to whether diabetic nephropathy was diagnosed,the above patients were divided into the control group(46 cases)and the confirmed group(60 cases).The expression levels of urinary microalbumin,urinary protein to creatinine ratio and glomerular filtration rate were analyzed.The diagnostic efficacy of different indicators in single detection and combined detection were analyzed by receiver operating characteristic curve(ROC)curve.Results Confirmed group the urine trace albumin and urinary albumin creatinine ratio are higher than the control group,serum levels of glo-merular filtration rate is lower than the control group,and the differences were statistically significant(all P<0.05).ROC curve analysis results show that the joint inspection area under the curve is 0.845,the sensitivity of 73.3%and 95.7%were higher than other single detection,and the differences were statistically significant(all P<0.05).Conclusion A single index has certain limitations in the clinical test of diabete nephropathy,and the combined detection can significantly improve the diagnostic efficiency and has clinical value.