血糖控制联合综合康复治疗对T2DM合并脑卒中患者的效果

Effect of Blood Glucose Control Combined with Comprehensive Rehabilitation Therapy on Patients with T2DM Complicated with Stroke

目的探究2型糖尿病(type 2 diabetes mellitus,T2DM)合并脑卒中患者治疗中选择血糖控制联合综合康复治疗的效果。方法回顾性选取2022年6月—2024年3月于福建医科大学附属第二医院就诊的76例T2DM合并脑卒中患者的临床资料,按照不同治疗方式分为对照组(二甲双胍缓释片联合综合康复治疗)和研究组(基于对照组治疗方案加入人胰岛素注射液),各38例。比较组间糖代谢水平(餐后2 h血糖、空腹血糖)、临床疗效、不良反应(昏迷、低血糖、恶心/呕吐、皮疹)发生风险。结果治疗4周后,研究组糖代谢水平低于对照组,差异有统计学意义(P均<0.05)。研究组临床疗效高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在二甲双胍与综合康复治疗基础上加入人胰岛素注射液治疗T2DM合并脑卒中患者,可有效控制糖代谢,疗效显著且不会增加不良反应发生风险,具有较高安全性。

Objective To explore the effect of blood glucose control combined with comprehensive rehabilitation therapy in the treatment of patients with type 2 diabetes mellitus(T2DM)complicated with stroke.Methods The clini⁃cal data of 76 T2DM patients with stroke who were treated in the Second Affiliated Hospital of Fujian Medical Univer⁃sity from June 2022 to March 2024 were retrospectively selected.According to different treatment methods,they were divided into the control group(metformin sustained release tablets combined with comprehensive rehabilitation treat⁃ment)and the study group(human insulin injection was added based on the treatment plan of the control group),with 38 cases in each group.The levels of glucose metabolism(2-hour postprandial blood glucose,fasting blood glucose),clinical efficacy,and the risk of adverse reactions(coma,hypoglycemia,nausea/vomiting,rash)were compared be⁃tween the two groups.Results After 4 weeks of treatment,the glucose metabolism level of the study group were lower than those of the control group,and the differences were statistically significant(both P<0.05).The clinical efficacy of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of metformin and comprehensive rehabilitation therapy,human insulin injection is added to treat patients with T2DM complicated with stroke,which can effectively control glucose metabolism,has significant cu⁃rative effect and does not increase the risk of adverse reactions,and has high safety.