四逆散联合桂枝甘草龙骨牡蛎加减治疗多囊卵巢综合征合并昼夜节律失调的临床效果

Clinical Efficacy of Modified Sini Powder Combined with Guizhi Gancao Longgu Muli Decoction in the Treatment of Polycystic Ovary Syndrome with Circadian Rhythm Disorder

目的探讨多囊卵巢综合征(PCOS)合并昼夜节律失调患者给予四逆散联合桂枝甘草龙骨牡蛎加减治疗的临床效果。方法选取2023年1月至2024年3月在本院接受治疗的100例PCOS合并昼夜节律失调患者,根据随机数字表法分为研究组(n=50)与对照组(n=50),对照组采用常规西药治疗,研究组在对照组基础上给予四逆散联合桂枝甘草龙骨牡蛎加减治疗,比较两组临床疗效、中医证候积分、激素水平、超声检查结果(卵泡数量、卵巢体积)、睡眠质量。结果研究组治疗有效率(98.00%)高于对照组(84.00%),差异有统计学意义(P<0.05);治疗后两组中医证候积分均降低,且研究组低于对照组,差异有统计学意义(P<0.05);治疗后两组血清黄体生成激素(LH)、睾酮(T)、雌二醇(E_(2))水平均降低,卵泡刺激素(FSH)水平均升高,且研究组LH、T、E_(2)水平低于对照组,FSH水平高于对照组,差异有统计学意义(P<0.05);治疗后两组卵泡数量减少,卵巢体积缩小,且研究组卵泡数量少于对照组,卵巢体积小于对照组,差异有统计学意义(P<0.05);治疗后两组匹兹堡睡眠质量指数(PSQI)评分均下降,且研究组PSQI评分低于对照组,差异有统计学意义(P<0.05)。结论四逆散联合桂枝甘草龙骨牡蛎加减结合西医治疗应用于PCOS合并昼夜节律失调患者中,能够提高临床疗效,改善中医证候,调节激素水平,改善患者卵巢异常,提升睡眠质量。

Objective To explore the clinical efficacy of modified Sini Powder combined with Guizhi Gancao Longgu Muli Decoction in the treatment of polycystic ovary syndrome(PCOS)with circadian rhythm disorder.Methods A total of 100 patients with PCOS and circadian rhythm disorder treated at our hospital from January 2023 to March 2024 were selected and randomly divided into a study group(n=50)and a control group(n=50)using a random number table.The control group received conventional Western medicine treatment,while the study group received modified Sini Powder combined with Guizhi Gancao Longgu Muli Decoction in addition to the conventional treatment.The clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,hormone levels,ultrasound examination results(number of follicles,ovarian volume),and sleep quality were compared between the two groups.Results The treatment efficacy in the study group(98.00%)was higher than that in the control group(84.00%),with statistically significant differences(P<0.05).After treatment,the TCM syndrome scores in both groups decreased,and the scores in the study group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the serum levels of luteinizing hormone(LH),testosterone(T),and estradiol(E_(2))decreased,and the levels of follicle-stimulating hormone(FSH)increased in both groups.The LH,T,and E_(2)levels in the study group were lower than those in the control group,while the FSH level was higher,with statistically significant differences(P<0.05).After treatment,the number of follicles decreased,and the ovarian volume reduced in both groups.The number of follicles and ovarian volume in the study group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the Pittsburgh Sleep Quality Index(PSQI)scores in both groups decreased,and the scores in the study group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion The combination of modified Sini Powder and Guizhi Gancao Longgu Muli Decoction with Western medicine treatment in patients with PCOS and circadian rhythm disorder can improve clinical efficacy,alleviate TCM syndromes,regulate hormone levels,improve ovarian abnormalities,and enhance sleep quality.