AFP、CEA、CA125检测对原发性肝癌介入术后残癌的评估价值

Evaluation Value of AFP,CEA,and CA125 Detection in Residual Cancer after Interventional Therapy for Primary Liver Cancer

目的分析甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)水平单独及联合检测对原发性肝癌介入术后残癌的评估价值。方法选择南乐中兴医院2019年3月至2021年3月收治行原发性肝癌介入术后残癌的70例患者作为实验组,另选择同期本院收治的70例原发性肝癌术后无残癌患者作为对照组。两组均检测AFP、CEA、CA125水平,采用Kendall’s tau-b(K)相关性分析AFP、CEA、CA125水平与原发性肝癌介入术后残癌发生的相关性,采用Logistic二元回归分析原发性肝癌介入术后残癌发生的影响因素,绘制ROC曲线分析AFP、CEA、CA125单独及联合检测对原发性肝癌介入术后残癌发生的诊断价值。结果两组性别、年龄、Child-Pugh分级对比,差异无统计学意义(P>0.05);实验组血清AFP、CEA、CA125水平均高于对照组,差异具有统计学意义(P<0.05);Kendall’s taub(K)相关性显示,原发性肝癌介入术后残癌发生与AFP、CEA、CA125水平呈正相关(r>0,P<0.05);经Logistic回归分析结果显示,AFP、CEA、CA125水平是原发性肝癌介入术后残癌发生的危险因素(OR>1,P<0.05);ROC曲线显示,AFP、CEA、CA125单独及联合检测对原发性肝癌介入术后残癌发生诊断的AUC分别为0.924(95%CI:0.884~0.965)、0.730(95%CI:0.642~0.817)、0.835(95%CI:0.769~0.901)、0.968(95%CI:0.941~0.994)。结论AFP、CEA、CA125检测对原发性肝癌介入术后残癌具有一定的评估价值,通过联合检测可提高预测价值,值得应用。

Objective To analyze the evaluation value of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125)levels in the detection of residual cancer after interventional therapy for primary liver cancer,both individually and in combination.Methods Seventy patients with residual cancer after interventional therapy for primary liver cancer treated at Nanle Zhongxing Hospital from March 2019 to March 2021 were selected as the experimental group.Another 70 patients without residual cancer after surgery during the same period were selected as the control group.Both groups were tested for AFP,CEA,and CA125 levels.Kendall’s tau-b(K)correlation analysis was used to analyze the correlation between AFP,CEA,and CA125 levels and the occurrence of residual cancer after interventional therapy for primary liver cancer.Logistic binary regression analysis was used to analyze the influencing factors of residual cancer after interventional therapy for primary liver cancer.ROC curves were drawn to analyze the diagnostic value of AFP,CEA,and CA125 levels individually and in combination for residual cancer after interventional therapy for primary liver cancer.Results There were no statistically significant differences in gender,age,and Child-Pugh classification between the two groups(P>0.05).The serum levels of AFP,CEA,and CA125 in the experimental group were higher than those in the control group,with statistically significant differences(P<0.05).Kendall’s tau-b(K)correlation analysis showed a positive correlation between the occurrence of residual cancer after interventional therapy for primary liver cancer and AFP,CEA,and CA125 levels(r>0,P<0.05).Logistic regression analysis showed that AFP,CEA,and CA125 levels were risk factors for residual cancer after interventional therapy for primary liver cancer(OR>1,P<0.05).ROC curve analysis showed that the AUCs for the diagnosis of residual cancer after interventional therapy for primary liver cancer using AFP,CEA,and CA125 individually and in combination were 0.924(95%CI:0.884~0.965),0.730(95%CI:0.642~0.817),0.835(95%CI:0.769~0.901),and 0.968(95%CI:0.941~0.994),respectively.Conclusion AFP,CEA,and CA125 detection has certain evaluation value for residual cancer after interventional therapy for primary liver cancer.Combined detection can improve predictive value and is worthy of application.