热休克蛋白70抑制剂的研究进展

Research progress of heat shock protein 70 inhibitors

热休克蛋白70(HSP70)广泛分布于细胞中,在应激状态下促进蛋白质的折叠和成熟。近年来,研究发现HSP70在多种恶性肿瘤细胞中高表达,并具有抑制细胞凋亡和干扰肿瘤免疫等功能,其可能成为肿瘤治疗的潜在靶点。本文作者对HSP70结构、作用机制以及当前抗肿瘤的HSP70小分子抑制剂研究进展进行综述,并讨论目前研究面临的问题与挑战,以期为后续HSP70抑制剂的开发提供参考。

Heat shock protein 70(HSP70)is widely distributed in cells and promotes protein folding and maturation process under stress.In recent years,it has been found that HSP70 is highly expressed in a variety of malignant tumor cells,which plays the roles of inhibiting apoptosis and interfering with tumor immunity,and may become a potential target for tumor therapy.Herein,the structure and mechanism of action of HSP70 and the current research progress of HSP70 small molecule inhibitors for antitumor therapy were reviewed,and the problems and challenges faced in the current research were discussed,which could provide references for the subsequent development of HSP70 inhibitors.