失眠、高敏C反应蛋白与腰痛和下肢疼痛共病之间关系的双向研究

Two way study on the relationship between insomnia,high-sensitivity C-reactive protein and comorbidity of low back pain and lower limb pain

目的探讨失眠、高敏C反应蛋白(hs-CRP)与慢性腰痛(LBP)和下肢疼痛共病之间关系的双向研究。方法选择该科2021年6月-2023年6月收治的60~85岁老年人289例进行研究,观察失眠、hs-CRP、慢性LBP、下肢疼痛之间的关系。结果慢性LBP患者和非慢性LBP人群年龄、性别、教育程度、慢性阻塞性肺病、hs-CRP、失眠发生率存在统计学意义(P<0.05);慢性下肢疼痛和非慢性下肢疼痛人群年龄、性别、教育程度、体力活动、hs-CRP、失眠差异存在统计学意义(P<0.05);慢性LBP合并下肢疼痛和非慢性LBP合并下肢疼痛人群年龄、性别、教育程度、hs-CRP和失眠差异存在统计学意义(P>0.05)。失眠和非失眠人群年龄、教育程度、体力活动、心血管疾病、慢性阻塞性肺疾病、hs-CRP等差异存在统计学意义(P<0.05)。剔除混杂变量影响后,失眠是影响慢性LBP的风险因素(P<0.05),不是影响慢性下肢痛和慢性LBP合并下肢痛的风险因素(P>0.05),hs-CRP不是影响慢性LBP、慢性下肢痛、慢性LBP合并下肢痛、失眠的风险因素(P>0.05);慢性LBP、慢性下肢痛不是影响失眠的风险因素(P>0.05),慢性LBP合并下肢痛是失眠的风险因素(P<0.05)。结论失眠和慢性腰痛和下肢疼痛之间不存在显著的双向相关,但失眠可增加慢性LBP的风险,同时患有LBP和下肢疼痛的患者存在失眠风险,hs-CRP对失眠、慢性腰痛和下肢疼痛的发生无明显影响。

Objective To investigate the relationship between insomnia,high-sensitivity C-reactive protein(hs-CRP),chronic low back pain(LBP)and comorbidity of lower limb pain.Methods From June 2021 to June 2023,289 elderly people aged 60-85 who underwent physical examination in our hospital were selected for the study.The relationship between insomnia,hs CRP,chronic LBP,and lower limb pain was observed.Results There were significant differences in age,sex,education level,incidence of chronic obstructive pulmonary disease,hs-CRP and insomnia between chronic LBP patients and non chronic LBP patients(P<0.05).There were significant differences in age,sex,education,physical activity,hs-CRP and insomnia between chronic lower limb pain and non chronic lower limb pain(P<0.05).There were significant differences in age,sex,education level,hs-CRP and insomnia between chronic LBP patients with lower limb pain and non chronic LBP patients with lower limb pain(P>0.05).There were significant differences in age,education,physical activity,cardiovascular disease,chronic obstructive pulmonary disease,hs-CRP between insomniacs and non insomniacs(P<0.05).After excluding the influence of mixed variables,insomnia wqs a risk factor affecting chronic LBP(P<0.05),not a risk factor affecting chronic lower limb pain and chronic LBP with lower limb pain(P>0.05),and hs-CRP was not a risk factor affecting chronic LBP,chronic lower limb pain,chronic LBP with lower limb pain,and insomnia(P>0.05).Chronic LBP and chronic lower limb pain were not risk factors for insomnia(P>0.05),while chronic LBP combined with lower limb pain were risk factors for insomnia(P<0.05).Conclusions There is no significant two-way correlation between insomnia and chronic low back pain and lower limb pain,but insomnia can increase the risk of chronic LBP.Patients with LBP and lower limb pain also have the risk of insomnia,and hs CRP has no significant impact on the occurrence of insomnia,chronic low back pain and lower limb pain.