外泌体非编码RNA在帕金森病诊断与治疗领域的研究进展

Research progress of exosomes non-coding RNAs in the diagnosis and treatment of Parkinson disease

帕金森病是一种常见的神经退行性疾病,以运动障碍为主要特征,目前帕金森病的病因和发病机制尚不完全清楚。外泌体是一种广泛存在于生物体液中的微小囊泡,携带了包括RNA在内的多种生物分子,参与细胞的各种生理活动和病理过程。越来越多的研究表明,外泌体非编码RNA在帕金森病中发挥着重要作用。本文就外泌体非编码RNA在帕金森病诊断与治疗领域的研究进展进行综述。尽管目前尚处于研究阶段,但随着科学研究的深入,基于外泌体非编码RNA的疗法将为帕金森病患者带来新的希望。

Parkinson disease is a common neurodegenerative disease,characterized by movement disorders,and the etiology and pathogenesis of Parkinson disease are still not fully understood.Exosomes are small vesicles widely present in biological body fluids that carry various biological molecules,including RNA,and are involved in various physiological activities and pathological processes of cells.An increasing number of studies have shown that exosome non-coding RNAs play an important role in Parkinson disease.This paper reviews the research progress of exosome non-coding RNAs in the diagnosis and treatment of Parkinson disease.Although it is still in the research stage,with the deepening of scientific research,therapies based on exosome non-coding RNAs will bring new hope to Parkinson disease patients.