摘要
Brain metastases are the most common central nervous system malignancies in adults.The popular view is that due to the existence of the blood–brain barrier,whether there are immune cells in the central nervous system has always been controversial.Current research shows that immune cells do exist in the central nervous system and play a vital role in the occurrence and development of brain metastasis.The central nervous system has a unique immune microenvironment,and the study of its mechanism is of great significance for the prediction and treatment of brain metastases.This article aims to discuss the components of the brain tumor microenvironment(TME)and immune mechanism of tumor brain metastasis,in the hopes of making better treatment through combination therapy.
基金
supported by Jilin Scientific and Technological Development Program(CN)(20190303146SF)(Jiuwei Cui)
General Program of National Natural Science Foundation of China(81874052)(Jiuwei Cui).
