Identification of leukocyte-lymphocyte ratio as a novel prognostic factor in Peripheral T-cell lymphoma

Purpose Peripheral T-cell lymphoma(PTCL)is notorious for its heterogeneity as well as poor prognosis.High mortality remains a challenge.Our study aims to assess whether the leukocyte-lymphocyte ratio(LLR)and neutrophil-lymphocyte ratio(NLR)can be applied as prognostic indexes for patients with PTCL and supplement the prognostic system of PTCL.Methods We reviewed the data of 108 newly diagnosed PTCL patients in the clinic.Theχ^(2) test was applied to contrast baseline characteristics between patients in different groups divided according to the cut-off value of LLR or NLR.The Kaplan-Meier method was adapted to develop the survival curve.The COX ratio risk regression model was used to identify the indexes related to patient survival.Results LLR≥10.30,NLR≥8.25,Eastern Cooperative Oncology Group(ECOG)score≥2,International prognostic index(IPI)score>2,Prognostic Index for T cell lymphoma(PIT)≥2,B symptom,Ann Arbor stage III-IV and high level of Lactic dehydrogenase(LDH)were poor prognosis factors impacting patients’overall survival(OS)by the univariate analysis.The multivariate analysis illustrated that only LLR≥10.30 was significantly related to OS(P all<0.05).Conclusion Overall,our analysis revealed that LLR≥10.30 was significantly associated with poorer OS and was a novel prognostic index for PTCL.