泮托拉唑+注射用血凝酶对上消化道出血治疗效果及炎症因子的影响分析

Effect of Pantoprazole+Injectable Hemagglutinin on Upper Gastrointestinal Bleeding and Its Influence of Inflammatory Factors

目的探究泮托拉唑+注射用血凝酶治疗上消化道出血患者的效果及对炎症因子水平的影响。方法随机选取2020年5月—2023年6月大通回族土族自治县人民医院收治的80例上消化道出血患者为研究对象,依据不同治疗方法分为两组,对照组(n=40)施以泮托拉唑治疗,研究组(n=40)施以泮托拉唑+注射用血凝酶治疗,比较两组患者治疗效果、炎症因子水平、凝血指标、不良反应发生率。结果研究组的治疗有效率为97.50%(39/40),高于对照组的82.50%(33/40),差异有统计学意义(χ^(2)=5.000,P<0.05)。治疗前,两组患者炎症因子水平比较,差异无统计学意义(P>0.05);治疗后,研究组的炎性因子水平优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者凝血指标比较,差异无统计学意义(P>0.05);治疗后,研究组的活化部分凝血活酶时间、血浆凝血酶原时间、凝血酶时间水平低于对照组,血浆纤维蛋白原水平高于对照组,差异有统计学意义(P均<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论上消化道出血患者应用泮托拉唑+注射用血凝酶治疗的效果显著,可改善炎症因子水平、凝血指标,且不增加不良反应,安全性较高。

Objective To explore the effect of pantoprazole+hemagglutinin injection on upper gastrointestinal hemorrhage and its influence on the level of inflammatory factors.Methods A total of 80 patients with upper gastrointestinal bleeding admitted to Datong Hui and Tu Autonomous County People's Hospital from May 2020 to June 2023 were randomly selected as the study subjects and divided into two groups according to the different treatment methods.The control group(n=40)was treated with pantoprazole,and the study group(n=40)was treated with pantoprazole+hemthrombin injection.The therapeutic effect,levels of inflammatory factors,coagulation indexes and incidence of adverse reactions were compared between the two groups.Results The effective rate of the study group was[97.50%(39/40)],higher than that of the control group[82.50%(33/40)],the difference was statistically significant(χ^(2)=5.000,P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors between the two groups(P>0.05).After treatment,the level of inflammatory factors in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in coagulation indexes between the two groups(P>0.05);after treatment,the levels of activated partial thromboplastin time,prothrombin time and thrombin time in the study group were lower than those in the control group,and the levels of fibrinogen was higher than those in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pantoprazole+hemagglutinin injection has a significant effect in the treatment of patients with upper gastrointestinal bleeding,which can improve the level of inflammatory factors and coagulation indexes,and does not increase adverse reactions,with high safety.