富马酸伏诺拉生片治疗复发性反流性食管炎患者的临床效果分析

Analysis of the Clinical Effect of Vonoprazan Fumarate Tablets in the Treatment of Patients with Recurrent Reflux Esophagitis

目的探讨富马酸伏诺拉生片在治疗复发性反流性食管炎患者中的临床疗效。方法简单随机选取2023年1月—2024年1月湄潭县人民医院收治的70例复发性反流性食管炎患者作为研究对象,以不同治疗方法将其分为观察组和对照组,各35例。对照组给予奥美拉唑肠溶胶囊治疗,观察组给予富马酸伏诺拉生片治疗。比较两组患者在胃肠激素指标、胃镜检查分级及症状改善情况方面的差异。结果在治疗结束后,两组患者的胃肠激素指标(胃泌素和胃动素)均升高,观察组胃泌素和胃动素分别为(284.53±17.75)pg/mL与(125.66±8.05)ng/L,高于对照组的(241.82±16.44)pg/mL和(118.85±7.14)ng/L,差异有统计学意义(t=10.443、3.744,P均<0.05)。观察组胃镜检查分级优于对照组,差异有统计学意义(P<0.05)。两组患者在治疗后的胸骨后灼痛、烧心、反酸得分均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论富马酸伏诺拉生片治疗复发性反流性食管炎患者,能更有效地改善患者的胃肠激素指标、胃镜检查结果和临床症状,显示出更佳的治疗效果。

Objective To evaluate the clinical effect of fumarate tablet in the treatment of patients with recurrent reflux esophagitis.Methods A total of 70 patients with recurrent reflux esophagitis admitted to Meitan County People's Hospital from January 2023 to January 2024 were simple randomly selected as the research objects.They were divided into observation group and control group by different therapeutic methods,with 35 cases in each group.The control group was treated with omeprazole enteric-coated capsules,and the observation group was treated with vonoprazan fumarate tablets.The differences in gastrointestinal hormone indexes,gastroscopy grading and the state of symptom improvement between the two groups were compared.Results After treatment,the gastrointestinal hormone indexes(gastrin and motilin)of the two groups increased,the gastrin and motilin in the observation group were(284.53±17.75)pg/mL and(125.66±8.05)ng/L,respectively,which were higher than(241.82±16.44)pg/mL and(118.85±7.14)ng/L in the control group,the differences were statistically significant(t=10.443,3.744,all P<0.05).The gastroscopy grading of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of substernal burning pain,heartburn and acid regurgitation in the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(all P<0.05).Conclusion In the treatment of patients with recurrent reflux esophagitis,fumarate tablet can improve gastrointestinal hormone indexes,gastroscopy results and clinical symptoms more effectively,showing better therapeutic effect.