腹腔镜-内镜联合手术治疗早期胃癌初期病例技术分析

Laparoscopy and endoscopy cooperative surgery for early gastric cancer:technical analysis of initial cases

目的:回顾性分析既往接受双镜联合手术的早期胃癌患者,评价该手术治疗早期胃癌的可行性。方法:回顾性收集2013年5月至2024年4月于北京大学肿瘤医院接受双镜联合手术的早期胃癌患者。手术方式包括内镜下黏膜切除(endoscopic submucosal dissection,ESD)联合腹腔镜淋巴结活检、经典腹腔镜-内镜联合手术(laparoscopic and endoscopic cooperative surgery,LECS)及其改良术式。收集患者临床病理特点、术后恢复指标、并发症及生存结局纳入分析。结果:共纳入9例患者,中位年龄64岁,男性6例(66.7%),女性3例(33.3%)。所有患者活检病理均为分化型胃癌。5例(55.6%)患者手术方式为ESD联合腹腔镜淋巴结活检,4例(44.4%)患者行腹腔镜辅助内镜全层切除及前哨淋巴结切检,平均麻醉时间(351.2±91.4)min,平均出血量(34.4±15.1)mL。术后出现3例(33.3%)并发症,包括1例胃排空障碍(CD2级),1例腹腔感染(CD2级),1例消化道穿孔(CD3级)。中位随访时间52个月,所有患者无复发及死亡。结论:双镜联合手术治疗早期胃癌具有可行性,其肿瘤学安全性仍需要进一步研究证实。LECS技术、适应证人群选择和前哨淋巴结切检准确率是进一步研究的重点。

Objective:To retrospectively analyze the efficiency of laparoscopic and endoscopic cooperative surgery(LECS)for early gastric cancer treatment.Methods:We retrospectively collected data from patients with early gastric cancer who underwent LECS at the Peking University Cancer Hospital&Institute between May,2013 and April,2024.Patients underwent endoscopic submucosal dissection(ESD)with laparoscopic lymph node biopsy,classical LECS,and other modified procedures.Additionally,clinical and pathological characteristics,postoperative recovery indicators,complications,and survival outcomes of the patients were analyzed.Results:Nine patients(median age:64 years),including six male(66.7%)and three female(33.3%)patients,were involved in this study.Biopsy revealed that all patients had welldifferentiated gastric cancer.Five patients(55.6%)underwent ESD with laparoscopic lymph node biopsy,and four patients(44.4%)underwent laparoscopically assisted endoscopic full-thickness resection and sentinel lymph node biopsy.Average anesthesia time was(351.2±91.4)min,and average blood loss was(34.4±15.1)mL.After surgery,three patients(33.3%)experienced complications,with one case each of gastric stasis(CD2),intra-abdominal infection(CD2),and gastrointestinal perforation(CD3).The median follow-up time was 52 months,and no cases of disease recurrence or death were observed.Conclusions:Overall,this study highlights the efficiency of LECS for early gastric cancer treatment.Future studies should assess its oncological safety,along with other technical aspects,patient selection criteria,and accuracy of sentinel lymph node biopsy,to facilitate widespread application of LECS.