胆汁酸-肠道菌群与慢性萎缩性胃炎肝郁脾虚病机的相关性探讨

Discussion on the Correlation between Bile Acid-intestinal Flora and Pathogenesis of Liver Depression and Spleen Deficiency in Patients with Chronic Atrophic Gastritis

肝郁脾虚是中医病机。当今随着人们生活方式的改变,符合肝郁脾虚病机的慢性萎缩性胃炎患者(chronic atrophic gastritis,CAG)逐渐增多。近年来,诸多研究将CAG的病因与胆汁酸代谢失常和肠道菌群紊乱联系起来。既往研究证实胆汁酸-肠道菌群的平衡符合肝脾协调的表现,越来越多的研究揭示可将胆汁酸-肠道菌群视作肝郁脾虚的微生物学基础。对胆汁酸-肠道菌群与CAG发病机制的相关性进行探讨,为CAG诊疗提供新的策略和研究靶点。