氧化石墨烯/壳聚糖水凝胶中羟基磷灰石的制备

Preparation of Hydroxyapatite in Graphene Oxide/Chitosan Hydrogel

羟基磷灰石(HA)具有良好的生物兼容性和骨传导性,但其机械强度低,制约了它的广泛使用.而氧化石墨烯(GO)和壳聚糖(CS)的复合材料独特的多孔状结构使其具有优秀的力学性能,因此将HA、GO和CS三者结合在一起所得到的复合物更能符合人们的需求.文章探究了交联剂作用下CS/GO复合水凝胶的制备,并以其为载体和模板在配位和静电吸引的协同效应下诱导调控HA的结晶.利用傅里叶红外光谱仪(FT-IR)、X线粉末衍射仪(XRD)和扫描电镜(SEM)对样品的结构和形貌进行了表征和测试.结果表明,在水热反应体系中磷酸肌酸二钠缓慢水解释放磷酸根更有利于类球形复合物HA/CS/GO的形成.该方法为制备具有生物相容性的HA/凝胶复合物提供了一条途径,并为其在潜在应用提供了基础研究和探讨.

Hydroxyapatite(HA)has been demonstrated to possess favorable biocompatibility and bone conduction properties.However,its relatively low mechanical strength represents a significant limitation to its broader utilization.The composite of graphene oxide(GO)and chitosan(CS)with a distinctive porous structure exhibits exceptional mechanical properties.It is therefore evident that the composite is better able to meet the needs of the public,when combined with HA,GO and CS.In this paper,the composite hydrogel of CS/GO is prepared under the action of a crosslinking agent and used as a carrier and template to induce the crystallization of HA under the synergistic effect of coordination and electrostatic attraction.The structures and morphologies of the samples are characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray powder diffraction(XRD),and scanning electron microscopy(SEM),respectively.The findings illustrate that the incremental hydrolysis of disodium phosphocreatine to yield phosphate ions in a hydrothermal reaction system is more conducive to the formation of spherical HA/CS/GO.This method provides a viable approach for the synthesis of HA/phosphorus gel composites with biocompatibility,thus establishing a foundation for further research and exploration into their potential applications.