复方杜仲健骨颗粒治疗膝骨关节炎的有效性及安全性Meta分析

Meta-analysis of Efficacy and Safety of Compound Duzhong Jiangu Granules in the Treatment of Knee Osteoarthritis

目的系统评价复方杜仲健骨颗粒治疗膝骨关节炎的有效性及安全性。方法按照PICOS原则对中国知网、万方数据知识服务平台、维普网、SinoMed、PubMed、Medline、Embase、Cochrane Library数据库进行文献检索,检索时间自建库至2023年10月底。对可量化分析的研究进行Meta分析,对有效率和疗效指标进行合并。结果共纳入5篇文章用于Meta分析。复方杜仲健骨颗粒的有效率高于对照组,差异有统计学意义(RR=1.12,95%CI:1.07~1.18,P<0.001)。在夜间卧床休息时疼痛或不适评分、从座位站立评分、最大行走距离评分、登下标准登机梯评分、在不平路行走评分、关节功能评定量表(Western Ontario and McMaster Universities Arthritis Index,WOMAC)评分方面,复方杜仲健骨颗粒与对照组比较,差异均有统计学意义(P<0.01)。在改善晨僵或起床后疼痛、登上标准登机梯评分、关节功能疗效评分方面,复方杜仲健骨颗粒与对照组比较,差异均无统计学意义(P>0.05)。所纳入的研究均未报道严重不良反应。结论联用复方杜仲健骨颗粒可提高治疗膝骨关节炎的疗效,在一定程度上缓解轻中度疼痛,促进关节功能恢复,但对于改善晨僵效果不佳,推荐用于早期的联合治疗,且安全性良好。

Objective To systematically evaluate the efficacy and safety of compound Duzhong Jiangu granules in the treatment of knee osteoarthritis.Methods According to PICOS principle,literature retrieval was carried out in CNKI,SinoMed,VIP,WanFang,PubMed,Medline,Embase and Cochrane Library,and the retrieval time was up to October 2023.Meta-analysis was performed on quantifiable studies,and the effective rate and efficacy indicators were combined.Results A total of 5 articles were included for Meta-analysis.The effective rate of compound guzhong Jiangu granules was higher than that of control group,the difference was statistically significant(RR=1.12,95%CI:1.07-1.18,P<0.001).Compared with the control group,there were significant differences in pain or discomfort scores during bed rest at night,standing from seat score,maximum walking distance score,getting off standard ladder score,walking on uneven road score and WOMAC score between compound duzhong jiangu granules and the control group(P<0.01).There were no significant differences in improving morning stiffness or pain after getting up,boarding standard ladder score and joint function efficacy score between compound Duzhong Jiangu Granules and control group(P>0.05).There were no serious adverse events were reported in the included studies.Conclusion Combined with compound guzhong jiangu granules can improve the therapeutic effect of knee osteoarthritis,relieve a mild to moderate pain to a certain extent,and promote the recovery of joint function,but it is not good for improving morning stiffness,so it is recommended for early combined treatment with good safety.