DTI-ALPS技术在脑类淋巴系统及脑小血管病评估中的研究进展

Recent advance in DTI-ALPS in evaluating cerebral glymphatic system and cerebral small vascular disease

脑类淋巴系统(GS)又称脑胶质淋巴系统,在维持大脑内环境稳定方面发挥着重要的作用。既往研究发现,脑小血管病(CSVD)的发生与GS功能障碍相关。沿血管周围间隙弥散张量成像分析(DTI-ALPS)技术作为神经影像学中的一种新兴无创方法,在评估中枢神经系统疾病GS功能方面取得了显著的进展。本文从DTI-ALPS技术的原理、DTI-ALPS指数与GS关系、DTI-ALPS指数与CSVD不同影像学标志物以及CSVD认知障碍关系等方面进行综述,以期为CSVD的早期诊断、进展和预后评估提供帮助。

Glymphatic system(GS),also known as glial-lymphatic system,plays a vital role in maintaining brain homeostasis.Previous research has established a link between cerebral small vessel disease(CSVD)and GS dysfunction.Diffusion tensor image analysis along the perivascular space(DTI-ALPS),an emerging non-invasive neuroimaging technique,has made significant strides in assessing GS function in central nervous system diseases.This review examines the DTI-ALPS principles,and relations of DTI-ALPS index with glymphatic circulation,various imaging markers of CSVD,and CSVD-related cognitive impairment,aiming to facilitate the early diagnosis,progression,and prognoses of CSVD.