五禽戏联合骨化三醇对绝经后骨质疏松症患者血钙浓度及骨密度的影响探讨

Observation on the Effect of Wuqinxi Combined with Calcitriol on Blood Calcium Concentration and Bone Mineral Density in Postmenopausal Osteoporosis Patients

目的探讨五禽戏联合骨化三醇治疗绝经后骨质疏松症患者的效果。方法随机选取2023年1—12月牡丹江医学院附属红旗医院治疗的228例绝经后骨质疏松症患者为研究对象,按治疗方法分为对照组、导引组、低剂量联合组和高剂量联合组,每组57例。对照组行常规治疗,导引组增加五禽戏训练,低剂量联合组口服小剂量骨化三醇,高剂量联合组口服大剂量骨化三醇,比较四组血钙浓度、骨密度和不良反应发生率。结果在治疗后低剂量联合组、高剂量联合组血钙浓度(2.32±0.20)mmol/L、(2.32±0.23)mmol/L高于于对照组和导引组(2.06±0.21)mmol/L、(2.04±0.18)mmol/L,差异有统计学意义(F=19.888,P<0.05)。导引组、低剂量联合组和高剂量联合组腰椎正位骨密度均大于对照组,高剂量联合组腰椎正位骨密度大于导引组;低剂量联合组左股骨颈骨密度大于对照组和导引组,高剂量联合组左股骨颈骨密度大于对照组、导引组和低剂量联合组,差异有统计学意义(P均<0.05)。4组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论五禽戏的训练,对患者骨密度的增加,具有积极的作用。在此基础上,联合骨化三醇用药,可改善患者的骨密度流失,高剂量用药的效果更为显著。

Objective To explore the effect of Wuqinxi combined with calcitriol in the treatment of postmenopausal osteoporosis.Methods A total of 228 patients with postmenopausal osteoporosis treated in Hongqi Hospital Affiliated to Mudanjiang Medical College from January to December 2023 were randomly selected as the research objects.According to the treatment methods,they were divided into control group,guidance group,low-dose combined group and high-dose combined group,with 57 cases in each group.The control group received routine treatment.The guidance group increased five-animal exercise training.The low-dose combined group was given low-dose calcitriol orally.The high-dose combined group was given high-dose calcitriol orally.The blood calcium concentration,bone mineral density and incidence of adverse reactions were compared between the four groups.Results After treatment,the serum calcium concentration in the low-dose combined group and the high-dose combined group(2.32±0.20)mmol/L,(2.32±0.23)mmol/L was higher than that in the control group and the guidance group(2.06±0.21)mmol/L,(2.04±0.18)mmol/L,and the difference was statistically significant(F=19.888,P<0.05).The bone mineral density of lumbar spine in the guidance group,low-dose combined group and high-dose combined group was higher than that in the control group,the bone mineral density of lumbar spine in the high-dose combined group was higher than that in the guidance group,the bone mineral density of left femoral neck in the low-dose combined group was higher than that in the con‐trol group and the guidance group,the bone mineral density of left femoral neck in the high-dose combined group was higher than that in the control group,the guidance group and the low-dose combined group,the differences were sta‐tistically significant(all P<0.05).There was no statistically significant difference in the comparison of the total inci‐dence of adverse reactions among the four groups(P>0.05).Conclusion The training of the five-animal exercise has a positive effect on the increase of bone mineral density in patients.On this basis,the combined use of calcitriol can improve the loss of bone mineral density in patients,and the effect of high-dose medication is more significant.