罗沙司他与琥珀酸亚铁对MHD肾性贫血患者铁蛋白、铁调素、白细胞介素-6、C反应蛋白水平的影响

The Effects of Rosacetam and Ferrous Succinate on the Levels of FER,Hep,IL-6,and CRP in Patients with MHD Renal Anemia

目的分析罗沙司他和琥珀酸亚铁对于维持性血液透析(maintenance hemodialysis,MHD)肾性贫血患者的疗效。方法目的选取河西学院附属张掖人民医院肾病科2022年1月—2023年7月期间收治的90例MHD肾性贫血患者,依照治疗方法不同分组,每组45例。所有患者均使用常规对症治疗,对照组加用琥珀酸亚铁,观察组加用罗沙司他+琥珀酸亚铁,分析疗效。结果观察组血清转铁蛋白饱和度为(39.02±3.61)%,高于对照组的(34.96±3.38)%,差异有统计学意义(t=5.507,P<0.05),观察组的铁调素、铁蛋白水平低于对照组,观察组的炎症因子水平低于对照组,差异有统计学意义(P均<0.05)。结论罗沙司他协同琥珀酸亚铁能进一步改善MHD肾性贫血患者的铁代谢,调节铁调素,减轻炎性反应,值得推荐。

Objective To analyze the efficacy of rosacetam and ferrous succinate in maintenance hemodialysis(MHD)patients with renal pelvic blood.Methods From January 2022 to July 2023,90 patients with MHD renal anemia admitted to the Nephrology Department of Zhangye People's Hospital Affiliated to Hexi University were objectively selected,and they were grouped by different treatment method with 45 patients each.All patients received routine symptomatic treatment,while the control group olded ferrous succinate and the observation group olded rosuvastat+ferrous succinate.The therapeutic effect was analyzed.Results The serum transferrin saturation of the observation group was(39.02±3.61)%,which was higher than the control group's(34.96±3.38)%,the difference was statistically significant(χ^(2)=5.507,P<0.05).The levels of Hepcidin and ferritin in the observation group were lower than those in the control group,the level of inflammation factors in the observation group were significantly lower than those in the control group,the differences were statistically significant(all P<0.05).Conclusion The combination of rosacetam and ferrous succinate can further improve iron metabolism,regulate ferritin,and alleviate inflammatory reactions in patients with MHD renal anemia,which is worth recommending.