肠道微生态在慢性肾脏病中的研究进展

Research progress on intestinal microecological in chronic kidney disease

慢性肾脏病(CKD)对全球公共健康有重大的影响,是导致非传染性疾病的发病率和病死率上升的重要因素之一。肠道微生态参与机体免疫、营养物质吸收等多种病理生理活动。随着2002年肠-肾轴这一概念的提出,研究者发现肾小球滤过率的下降导致尿毒症毒素在肠道中蓄积,破坏肠道黏膜屏障,导致尿毒症毒素易位,激活全身氧化应激反应进一步促进CKD的进展。本文综述了肠道微生物群的功能、肠-肾轴以及微生物制剂在慢性肾脏病中的应用。

Chronic kidney disease(CKD)has a significant impact on global public health and is one of the important factors leading to the rise of incidence rate and mortality of non communicable diseases.Intestinal microecology is involved in many pathophysiological activities,such as immunity and nutrient absorption.With proposal of the concept of intestine-kidney axis in 2002,researchers found that the decline of glomerular filtration rate led to accumulation of uremic toxins in intestine,destroyed the intestinal mucosal barrier,led to the translocation of toxins,activated the systemic oxidative stress response,further promoted the progress of CKD.This article reviewed the function of gut microbiota,intestine-gut kidney axis,and the application of microbial preparations in CKD.