基于Web of Science的挥发性有机化合物无创诊断肿瘤文献计量与可视化分析

Bibliometrics and visualization analysis of non-invasive cancer diagnosis using volatile organic compounds based on Web of Science

目的对近20年使用挥发性有机化合物(VOCs)进行肿瘤无创诊断的研究展开文献计量及可视化分析,总结其研究现状、不足及发展趋势,为未来临床实施应用提供参考。方法以“neoplasia”和“volatile organic compound”为共同主题,采用主题词和自由词结合的方式,检索2002年1月1日至2022年10月26日发表在Web of Science核心合集数据库的VOCs无创诊断肿瘤相关研究,通过Citespace和VOSviewer软件生成知识图谱,对年度出版物、国家、作者机构、出版物、参考文献及关键词进行可视化分析。结果经检索共纳入641项研究,年度发文量整体呈上升趋势。“肺癌”“呼出气”一直是该领域核心组成部分;传感器检测技术在更多癌症中应用和发展,以及探索潜在特异性生物标志物成为新的研究趋势。结论利用VOCs进行肿瘤无创诊断将继续成为一个活跃的研究领域,但追求创新的同时,还需考虑实际需求,如果没有统一的操作标准,不是特定癌种可靠且可重复的生物标志物群,VOCs的临床应用依然会受到极大限制。

Objective To carry out bibliometric and visual analysis of non-invasive cancer diagnosis using volatile organic compounds(VOCs)over the past 20 years,to characterize international status,shortfalls,and trends in this field,and to provide references in the future clinical application.Methods Taking"neoplasia"and"volatile organic compound"as common themes,the combination of subject words and free words was adopted.Research on VOCs noninvasive diagnosis of tumors,from January 1,2002 to October 26,2022 were retrieved from the Web of Science Core Collection database.CiteSpace and VOSviewer were used to generate network maps and identify the annual publications,top countries,authors,institutions,journals,references,and keywords.Results After screening,641 articles were included.Overall,there has been an increase in annual publications in this area,with an overall upward trend.The analysis of lung cancer and exhaled breath occupied a prominent position of research in this area.The application and development of sensor detection technology in more cancers,and the exploration of potential specific biomarkers had become a new research trend.Conclusions The study of non-invasive cancer diagnosis using VOCs will continue to be a hot field.However,practical requirements must also be considered while pursuing innovative approaches.Without uniform operational standards,and without a reliable and reproducible list of VOCs to identify specific cancer types,the clinical utility of VOCs testing will be extremely limited.