甘草泻心口腔护理液改善脑卒中患者口腔状态的临床研究

Gancao Xiexin oral care solution for improving oral state of stroke patients

目的探讨甘草泻心口腔护理液(甘草泻心口护液)改善脑卒中患者口腔状态的效果。方法采用随机对照试验,选取2021年12月至2023年10月在河南中医药大学第一附属医院神经外科治疗的80例脑卒中患者作为研究对象,以随机数表法分为对照组和观察组,各40例。对照组男25例、女15例,年龄(52.20±4.95)岁,病程(1.84±0.53)个月,予以生理盐水进行口腔护理,2次/d,20 ml/次,治疗10 d;观察组男26例、女14例,年龄(52.20±6.37)岁,病程(1.84±0.53)个月,采用甘草泻心口护液进行口腔护理,2次/d,50 ml/次,治疗10 d。对比两组患者治疗前后牙龈指数、菌斑指数、口腔pH值、口唇湿润度、口腔异味、口腔黏膜炎及不良反应发生情况。统计学方法采用t检验、χ^(2)检验。结果治疗前,两组患者牙龈指数、菌斑指数、口腔pH值、口唇湿润度、口腔异味发生情况比较,差异均无统计学意义(均P>0.05)。治疗5 d、10 d,观察组牙龈指数、菌斑指数、口唇湿润度及口腔异味情况均低于对照组[(1.23±0.42)分比(1.98±0.16)分、(0.65±0.48)分比(1.10±0.30)分、(1.44±0.50)分比(1.93±0.27)分、(0.78±0.48)分比(1.20±0.52)分、(0.65±0.53)分比(0.98±0.42)分、(0.15±0.36)分比(0.65±0.53)分、(2.28±0.45)分比(2.50±0.51)分、(1.45±0.60)分比(1.90±0.38)分],口腔pH值均高于对照组[(6.53±0.08)比(6.42±0.11)、(6.98±0.10)比(6.62±0.14)],差异均有统计学意义(t=10.506、4.987、5.416、3.814、3.086、4.936、2.096、4.007、5.115、13.234,均P<0.05)。治疗后,观察组口腔黏膜炎发生率为5.0%(2/40),低于对照组的15.0%(6/40),差异有统计学意义(χ^(2)=6.486,P<0.05)。两组患者治疗期间均无不良反应情况发生。结论甘草泻心口护液能有效改善脑卒中患者口腔状态,操作简便安全,患者依从性高,值得临床进一步推广应用。

Objective To explore the role of Gancao Xiexin oral care solution for improving the oral state of stroke patients.Methods Eighty stroke patients hospitalized at department of Neurosurgery,First Hospital,Henan University of Chinese Medicine from December 2021 to October 2023 were selected for the randomized controlled trial.They were divided into a control group and an observation group by the random number table method,with 40 cases in each group.There were 25 males and 15 females in the control group;they were(52.20±4.95)years old.There were 26 males and 14 females in the observation group;they were(52.20±6.37)years old.The control group used 0.9%sodium chloride injection(normal saline,NS)for oral care,the observation group used Gancao Xiexin oral care solution for oral care.The gingival index,plaque index,oral pH,oral moisture,oral odor,and oral mucositis before and after the treatment and adverse reactions were compared between the two groups.t andχ^(2) tests were applied.Results Before the treatment,there were no significant differences in the gingival index,plaque index,oral pH,oral moisture,and oral odor between the two groups(all P>0.05).After 5 and 10 days'treatment,the scores of gingival index,plaque index,oral moisture,and oral odor in the observation group were lower than those in the control group[(1.23±0.42)vs.(1.98±0.16),(0.65±0.48)vs.(1.10±0.30),(1.44±0.50)vs.(1.93±0.27),(0.78±0.48)vs.(1.20±0.52),(0.65±0.53)vs.(0.98±0.42),(0.15±0.36)vs.(0.65±0.53),(2.28±0.45)vs.(2.50±0.51),and(1.45±0.60)vs.(1.90±0.38)];the oral pH values in the observation group were higher than those in the control group[(6.53±0.08)vs.(6.42±0.11)and(6.98±0.10)vs.(6.62±0.14)];there were statistical differences(t=10.506,4.987,5.416,3.814,3.086,4.936,2.096,4.007,5.115,and 13.234;all P<0.05).After the treatment,the incidence of oral mucositis in the observation group was lower than that in the control group[(5.0%(2/40)vs.15.0%(6/40)],with a statistical difference(χ^(2)=6.486;P<0.05).No adverse reactions occurred in both groups.Conclusion Gancao Xiexin oral care solution can improve the oral health status of stroke patients and is easy and safe to operate,with high patient compliance,so it is worth being clinically generalized.