肌少症指数与老年2型糖尿病肾病的相关性分析

Correlation analysis between sarcopenia index and type 2 diabetic nephropathy in elderly patients

目的:研究并分析肌少症指数与老年2型糖尿病肾病的相关性。方法:选取2021年11月至2023年11月本院收治的老年2型糖尿病患者82例为研究对象,按照24h尿清蛋白排泄率、肾小球滤过率估计值等指标将入选患者分为单纯糖尿病组40例、糖尿病肾病组42例。对两组相关临床资料进行收集和对比,评估指标包括一般资料、血糖水平、血脂水平、血压水平、肾功能水平,并计算肌少症指数,对老年2型糖尿病肾病的影响因素进行分析,评价肌少症指数与老年2型糖尿病肾病的相关性。结果:单因素分析显示,病程、空腹血糖、餐后2h血糖、糖化血红蛋白、血肌酐、肾小球滤过率估计值、24h尿清蛋白排泄率、肌少症指数与糖尿病肾病的发生有关(P<0.05)。多因素分析显示,病程、糖化血红蛋白、肾小球滤过率估计值、24h尿清蛋白排泄率、肌少症指数与糖尿病肾病的发生有关(P<0.05)。肌少症指数预测老年2型糖尿病肾病的ROC曲线下面积为0.720,最佳截断值为68.447,灵敏度为0.694,特异度为0.633(P<0.001)。结论:在老年2型糖尿病肾病中,肌少症指数是一个重要的独立危险因素,其与糖尿病肾病的发生有着密切的相关性,可利用该指标预测评估糖尿病肾病,具有重要的临床价值。

Objective:To study and analyze the correlation between sarcopenia index and elderly type 2 diabetic nephropathy.Methods:82 cases of elderly patients with type 2 diabetes in our hospital from November 2021 to November 2023 were selected as the research object,according to the 24h urinary albumin excretion rate,the selected patients were divided into 40 cases of simple diabetes group and 42 cases of diabetic nephropathy group.The clinical data of the two groups were collected and com-pared.The evaluation indexes included general data,blood glucose level,blood lipid level,blood pressure level,renal function level,the influencing factors of elderly type 2 diabetic nephropathy were analyzed,and the correlation between sarcopenia index and elderly type 2 diabetic nephropathy was evaluated.Results:Single factor analysis showed that the course of disease,fast-ing blood glucose,postprandial 2H blood glucose,glycosylated hemoglobin,serum creatinine,estimated glomerular filtration rate,24h urinary albumin excretion rate,sarcopenia index was associated with the development of diabetic nephropathy(P<0.05).Multivariate analysis showed that course of disease,glycosylated hemoglobin,estimated glomerular filtration rate,24h urinary albumin excretion rate,sarcopenia index were associated with the occurrence of diabetic nephropathy(P<0.05).The area under ROC curve of sarcopenia index for predicting elderly patients with type 2 diabetic nephropathy was 0.720,the best cut-off value was 68.447,the sensitivity was 0.694,and the specificity was 0.633(P<0.001).Conclusion:In elderly pa-tients with type 2 diabetic nephropathy,sarcopenia index is an important independent risk factor,which is closely related to the occurrence of diabetic nephropathy,this index can be used to predict and evaluate diabetic nephropathy,which has important clinical value.