消渴方联合二甲双胍治疗2型糖尿病患者的疗效观察

Thirst-Quenching Formula Combined with Metformin in the Treatment of Patients with Type 2 Diabetes Mellitus

目的探讨消渴方联合二甲双胍治疗2型糖尿病患者的临床疗效。方法选择淮安市楚州中医院肾病内分泌科2021年12月至2023年12月收治的2型糖尿病患者80例,按照随机方式分为各40例的两组,对照组二甲双胍治疗,观察组再加消渴方治疗。对比两组临床疗效、血糖水平、中医证候积分与不良反应。结果观察组总疗效率92.50%,较对照组75.00%高,P<0.05。两组治疗前空腹血糖、餐后2 h血糖水平及糖化血红蛋白相比,P>0.05;两组治疗后血糖指标对比,观察组均低于对照组,P<0.05。两组治疗前中医证候积分对比,P>0.05;两组治疗后多食易饥、口渴喜饮、五心烦热、气短懒言积分对比,观察组积分均明显更低,P<0.05。两组不良反应发生率对比,P>0.05。结论消渴方联合二甲双胍治疗2型糖尿病的效果可靠,能提高血糖控制效果,改善患者症状,且不良反应少。

Objective:Exploring the clinical efficacy of thirst-quenching formula combined with metformin in the treatment of patients with type 2 diabetes mellitus.Methods:Eighty cases of type 2 diabetes mellitus admitted to the Nephrology and Endocrinology Department of Huai'an Chuzhou Hospital of Traditional Chinese Medicine from December 2021 to December 2023 were randomly divided into two groups of 40 cases each,with metformin treatment in the control group and thirst-quenching formula in the observation group.The clinical efficacy,blood sugar level、TCM syndrome score and adverse reactions were compared between the two groups.Results:The total efficacy rate of the observation group was 92.50 per cent,which was higher than that of the control group,75.00 per cent,p<0.05.Compared with fasting blood glucose before treatment、2 h blood glucose level after meal and glycosylated hemoglobin in the two groups,P>0.05;Comparison of blood glucose indicators after treatment of the two groups,the observation group are lower than the control group,P<0.05.Before treatment,the scores of TCM syndromes in the two groups were compared,P>0.05;After treatment,the scores of the two groups were significantly lower,P<0.05.The incidence of adverse reactions between the two groups was compared,P>0.05.Conclusion:Xiaoke recipe combined with metformin is effective in treating patients with type 2 diabetes mellitus,which can effectively control blood sugar level and improve patients'symptoms with few adverse reactions.