玉屏风颗粒在急性淋巴细胞白血病患儿维持治疗中的应用效果

Application effect of Yupingfeng granules in maintenance therapy of children with acute lymphoblastic leukemia

目的探讨玉屏风颗粒在急性淋巴细胞白血病(ALL)患儿维持治疗中的应用效果。方法依据治疗方式的不同将60例ALL患儿分为联合组和常规组,每组30例,常规组患儿维持治疗期间给予常规化疗,联合组患儿维持治疗期间在常规化疗基础上联合玉屏风颗粒治疗。比较两组患儿的血常规指标、免疫球蛋白(Ig)水平、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平、辅助性T细胞(Th)水平、调节性T细胞(Treg)水平及不良反应发生情况。结果治疗后,联合组患儿中性粒细胞计数、白细胞计数均低于常规组,血小板计数和血红蛋白水平均高于常规组,差异均有统计学意义(P﹤0.05)。治疗后,联合组患儿IgA、IgM、IgG水平及Th17、Th22细胞水平均高于常规组,Treg细胞水平低于常规组,差异均有统计学意义(P﹤0.05)。治疗后,联合组患儿CD3^(+)、CD4^(+)水平及CD4^(+)/CD8^(+)均高于常规组,CD8^(+)水平低于常规组,差异均有统计学意义(P﹤0.05)。联合组患儿维持治疗期间不良反应总发生率为3.33%,明显低于常规组患儿的30.00%,差异有统计学意义(P﹤0.01)。结论玉屏风颗粒可增强ALL维持治疗患儿的免疫功能,改善生化指标,降低不良反应发生率。

Objective To explore the application effect of Yupingfeng granules in maintenance therapy of children with acute lymphoblastic leukemia(ALL).Method According to different treatment methods,60 ALL children were divided into combined group and conventional group,with 30 cases in each group.The conventional group received conventional chemotherapy during maintenance treatment,while the combined group received Yupingfeng granules on the basis of conventional chemotherapy during maintenance treatment.The blood routine indicators,immunoglobulin(Ig)levels,T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels,helper T cell(Th)levels,regulatory T cell(Treg)levels,and incidence of adverse reactions were compared between the two groups.Result After treatment,the neutrophil count and white blood cell count in the combined group were lower than those in the conventional group,while the platelet count and hemoglobin level were higher than those in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the levels of IgA,IgM,IgG and Th17,Th22 cells in the combined group were higher than those in the conventional group,while the level of Treg cell was lower than that in the conventional group,and the differences were statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the combined group were higher than those in the conventional group,while the level of CD8^(+)was lower than that in the conventional group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions during maintenance treatment in the combined group was 3.33%,which was significantly lower than 30.00%in the conventional group,and the difference was statistically significant(P<0.01).Conclusion Yupingfeng granules can enhance the immune function of children undergoing maintenance therapy of ALL,improve biochemical indicators,and reduce the incidence of adverse reactions.