血清细胞程序性死亡蛋白5、信号转导与转录激活因子1水平与宫颈鳞状细胞癌患者临床特征及预后的关系

Relationship between serum levels of programmed cell death 5,signal transduction and activator of transcription 1 and clinical characteristics and prognosis of cervical squamous cell carcinoma patients

目的探讨血清细胞程序性死亡蛋白5(PDCD5)、信号转导与转录激活因子1(STAT1)水平与宫颈鳞状细胞癌(CSCC)患者临床特征及预后的关系。方法选取68例CSCC患者和60例健康体检者,分别纳入CSCC组和健康组。比较两组受试者及不同临床特征CSCC患者血清PDCD5、STAT1水平。CSCC患者预后的影响因素采用多因素Cox回归模型分析。结果CSCC组患者血清PDCD5、STAT1水平均明显低于健康组,差异均有统计学意义(P﹤0.01)。有淋巴结转移、分化程度为低分化、临床分期为Ⅲ+Ⅳ期CSCC患者血清PDCD5、STAT1水平分别低于无淋巴结转移、分化程度为中高分化、临床分期为Ⅰ+Ⅱ期患者,差异均有统计学意义(P﹤0.05)。随访12个月,68例CSCC患者中,生存62例,死亡6例。多因素Cox分析结果显示,血清PDCD5﹤0.75 ng/ml、STAT1﹤54.69μg/L、淋巴结转移均是CSCC患者预后不良的独立危险因素(P﹤0.05)。结论CSCC患者血清PDCD5、STAT1水平较低,血清PDCD5﹤0.75 ng/ml、STAT1﹤54.69μg/L、淋巴结转移均是CSCC患者预后不良的独立危险因素。

Objective To investigate the relationship between serum levels of programmed cell death 5(PDCD5),signal transduction and activator of transcription 1(STAT1)and clinical characteristics and prognosis of cervical squamous cell carcinoma(CSCC)patients.Method A total of 68 CSCC patients and 60 healthy individuals were selected and included in the CSCC group and the healthy group,respectively.The serum levels of PDCD5 and STAT1 between two groups of subjects,as well as in CSCC patients with different clinical characteristics were compared.The multivariate Cox regression model was used to analyze the prognostic influencing factors of CSCC patients.Result The serum levels of PDCD5 and STAT1 in the CSCC group were significantly lower than those in the healthy group,and the differences were statistically significant(P<0.01).The serum levels of PDCD5 and STAT1 in CSCC patients with lymph node metastasis,low differentiation,and clinical stage III+IV were lower than those in patients without lymph node metastasis,moderate to high differentiation,and clinical stage I+II,and the differences were statistically significant(P<0.05).After 12 months of follow-up,62 cases survived and 6 cases died during 68 patients with CSCC.Multivariate Cox analysis showed that serum PDCD5<0.75 ng/ml,STAT1<54.69μg/L,lymph node metastasis were independent risk factors for poor prognosis in CSCC patients(P<0.05).Conclusion CSCC patients have low levels of serum PDCD5 and STAT1,and serum PDCD5<0.75 ng/ml,STAT1<54.69μg/L,and lymph node metastasis are independent risk factors for poor prognosis in CSCC patients.