肠道菌群、炎症免疫细胞在冠状动脉微血管疾病和高血压发生发展中的作用研究进展

Research Progress of Role of Intestinal Flora and Inflammatory Immune Cells in Occurrence and Development of Coronary Microvascular Disease and Hypertension

肠道菌群是指定植在人体肠道内,对宿主健康产生影响的微生物群体。肠道菌群失调(如抗生素滥用、高脂饮食等因素导致有益菌减少、有害菌增多)可引发肠道局部乃至全身的炎症反应。肠道菌群通过炎症免疫细胞影响冠状动脉微血管疾病(CMVD)、高血压等相关疾病的发生发展。肠道菌群失调可引发炎症反应,促进CMVD、高血压等疾病的进展。未来可对肠道菌群与CMVD、高血压等疾病的关系进行深入探索,从新的视角认识肠道菌群通过炎症反应致病的有关机制,以期为疾病的治疗提供新思路。

Intestinal flora is a group of microorganisms that are specially planted in the human intestine and have an impact on the health of the host.Intestinal flora is imbalanced(such as a decrease in beneficial bacteria and an increase in harmful bacteria caused by factors such as antibiotic abuse and high-fat diet)can cause local and even systemic inflammatory reactions in the intestine.Intestinal flora affects the occurrence and development of related diseases such as coronary microvascular disease(CMVD)and hypertension through inflammatory immune cells.The intestinal flora imbalance can cause inflammation and promote the development of CMVD and hypertension.In the future,the relationship of intestinal flora with CMVD,hypertension and other diseases can be further explored,and the pathogenesis of intestinal flora through inflammatory response can be understood from a new perspective,so as to provide new ideas for the treatment of diseases.