血清肌酐与胱抑素C比值与骨质疏松关系的研究进展

Research Progress in Correlation between Serum Creatinine to Cystatin C Ratio and Osteoporosis

血清肌酐与胱抑素C以往被作为反映肾功能的指标。近年来研究证明,血清肌酐与胱抑素C比值(CCR)与肌肉含量相关,可用来初步筛查肌少症,即CCR可用于识别肌少症风险人群。CCR降低可能预示着肌肉含量的减少或肌肉功能的下降。基于此理论并考虑到肌肉与骨骼之间的密切关系,CCR或可作为预测骨质疏松风险的潜在工具。2型糖尿病所引发的肾功能损伤、胰腺功能异常及同型半胱氨酸水平变化等均显著影响体内的肌酐和胱抑素C水平。除骨质疏松、2型糖尿病外,CCR是否可以作为其他疾病的相关预测因子还需进一步研究。

Serum creatinine and cystatin C were used as indicators of renal function.In recent years,it has been proved that the serum creatinine to cystatin C ratio(CCR)is related to muscle content,which can be used to initially screen for sarcopenia,that is,CCR can be used to identify risk population of sarcopenia.When CCR decreases,it may indicate a decrease in muscle mass or a decline in muscle function.Based on this theory and considering the close relationship between muscle and bone,CCR can also be used as a potential tool to predict the risk of osteoporosis.The damage of renal function,heteropancreatism and the level change of homocysteine caused by type 2 diabetes mellitus significantly affect the levels of creatinine and cystatin C.Besides osteoporosis and type 2 diabetes melltitus,whether CCR can be used as a relevant predictor of other diseases needs further studies.