摘要
肝硬化是多种肝病的终末期阶段.一旦肝硬化进展至失代偿期,将会发生各种并发症,降低患者生存质量及生存率.代谢组学技术通过分析患者体内的代谢物,揭示了与肝硬化进展密切相关的代谢变化,为肝硬化及其并发症的早期诊断和预后评估提供新的生物标志物,对改善患者预后具有一定价值.本文对代谢组学在肝硬化及其并发症中的应用进展作一综述.
Liver cirrhosis is the end stage of a variety of liver diseases.Once liver cirrhosis progresses to the decompensated stage,various complications will develop,which will greatly reduce the quality of life and survival rate of patients.Metabolomics can reveal the metabolic changes closely related to the progression of liver cirrhosis by analyzing the metabolites in patients and provide new biomarkers for the early diagnosis and prognosis evaluation of liver cirrhosis and its complications,which is of importance in improving the prognosis of patients.This article reviews the recent advances in the application of metabolomics in liver cirrhosis and its complications.
作者
林果
陈纪宏
尹宇航
赵浩南
刘壮
祁兴顺
Guo Lin;Ji-Hong Chen;Yu-Hang Yin;Hao-Nan Zhao;Zhuang Liu;Xing-Shun Qi(Department of Gastroenterology,General Hospital of Northern Theater Command,Shenyang 110840,Liaoning Province,China;Graduate School of Dalian Medical University,Dalian 116044,Liaoning Province,China;Postgraduate College,China Medical University,Shenyang 110122,Liaoning Province,China;Graduate School of Shenyang Pharmaceutical University,Shenyang 110016,Liaoning Province,China)
出处
《世界华人消化杂志》
CAS
2024年第8期561-568,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金,No.82270659.
