幽门螺杆菌感染引发非酒精性脂肪性肝病机制的研究进展

Research progress on the mechanism of non-alcoholic fatty liver disease induced by Helicobacter pylori infection

非酒精性脂肪性肝病(NAFLD)是引起肝功能异常较常见的疾病,通常由于各种原因引起肝脏代谢脂肪的能力减弱,致使摄入的脂类物质难以正常代谢,导致肝内脂肪过度沉积,病情进展或致肝硬化、肝细胞癌,随着临床对NAFLD研究范围的扩大,发现其与幽门螺杆菌(Hp)感染密切相关,文章就Hp感染在NAFLD中作用机制的研究进展作一综述,以为NAFLD的临床预防和治疗提供思路和参考。

Nonalcoholic fatty liver disease(NAFLD)is a common disease that causes abnormal liver function.It is usually caused by various reasons that weaken the liver's ability to metabolize fat,making it difficult to metabolize the intake of lipid substances normally,resulting in excessive deposition of fat in the liver.This has been characterized as a global public health challenge event.The prevalence of NAFLD is on the rise globally,affecting 20%to 45%of the general population.There is currently no approved treatment plan for the progression of the disease or the development of liver cirrhosis or hepatocellular carcinoma.With the expansion of clinical research on NAFLD,it has been found that it is closely related to Helicobacter pylori(Hp)infection.This article reviews the research progress on the mechanism of Hp infection in NAFLD,providing new methods for the clinical prevention and treatment of NAFLD.