小檗碱抗胰腺癌药理作用及其机制的研究进展

Research Progress in Pharmacological Effects and Mechanisms of Berberine against Pancreatic Cancer

小檗碱是一种具有广泛药理作用的生物活性物质,除了抗炎、抗菌、抗病毒、抗高血压、抗缺氧、降血糖、降血脂等作用外,还具有抗肿瘤作用。近年来,国内外科研团体对小檗碱在抗胰腺癌领域的作用进行了诸多深入研究,取得不少重要成果。因此,该文主要就小檗碱的抗胰腺癌作用及其药理机制进行了综述,并对相关研究做了分析。

Berberine is a bioactive substance with a wide range of pharmacological effects.It has the effects against tumors in addition to anti-inflammatory,antibacterial,antiviral,antihypertensive,anti-hypoxic,hypoglycemic,and hypolipidemic effects.In recent years,domestic and foreign scientific research groups have conducted many in-depth studies on the roles of berberine in the field of anti-pancreatic cancer and achieved many important results.Therefore,the anti-pancreatic cancer effect and pharmacological mechanism of berberine are reviewed,and related studies are analyzed in this article.