癫痫与肠道菌群相关性的研究进展

Research progress on the correlation between epilepsy and gut microbiota

癫痫是一种慢性脑部疾病,给社会和患者自身带了沉重的负担。癫痫与肠道菌群之间的相关性逐渐为人们所重视。免疫炎症反应、神经递质和短链脂肪酸可能是肠道菌群影响癫痫发生发展的重要因素。生酮饮食是癫痫的传统非药物治疗手段,能够有效改善肠道微生态环境控制癫痫的发生,粪菌移植和益生菌干预也是近年来癫痫治疗的研究热点,此文对相关研究进行了归纳,对相关病因学基础、发病机制做了系统综述,以期为临床癫痫治疗研究提供新的思路。

Epilepsy is a chronic brain disease that places a heavy burden on society and patients themselves.The correlation between epilepsy and gut microbiota is becoming increasingly important.The gut microbiota may influence the development of epilepsy through immune-inflammatory responses,neurotransmitters,and short-chain fatty acids.Ketogenic diet is a traditional non-drug treatment method for epilepsy,which can effectively improve the intestinal microenvironment to control the occurrence of epilepsy.Fecal microbiota transplantation and probiotic intervention have also been research hotspots in epilepsy treatment in recent years.This article summarizes relevant research,and systematically reviews relevant etiological basis and pathogenesis,providing new clues for future clinical treatment research on epilepsy.