不同预后的全聋型突发性聋患者治疗前失匹配负波的探讨

A Study of Mismatch Negativity in Patients with Total Deafness of Sudden Hearing Loss with Different Prognosis

目的探讨不同预后单侧全聋型突发性聋(简称突聋)患者失匹配负波(mismatch negativity,MMN)的特点,评估MMN与其预后的关系。方法对51例单侧全聋型突发性聋患者在治疗前进行纯音测听(PTA)以及MMN检查,治疗10 d后再复查PTA,根据预后分为无效组、有效组,观察两组间MMN潜伏期及波幅的特点,并比较其与正常对照组(26例)的差异。结果51例突聋患者和26例正常组均引出MMN波形,其中有效组(29例)、无效组(22例)MMN潜伏期均较正常组明显缩短,均有统计学差异(P<0.05),但无效组与有效组间MMN潜伏期无明显统计学差异(P>0.05);三组间波幅均无统计学差异(P>0.05)。结论突聋患者MMN潜伏期明显缩短,无效组、有效组间MMN潜伏期、波幅没有差异。

Objective To investigate the characteristics of mismatch negativity(MMN)in patients with total deafness of sudden hearing loss with different prognosis,and to assess whether MMN is associated with the prognosis of sudden hearing loss patients.Methods Fifty-one cases of sudden hearing loss with unilateral total deafness were selected for pure tone audiometry(PTA)and auditory MMN examination before treatment,and 26 subjects with mornal hearing were included as the normal group.After routine treatment for 10 days according to the guidelines for sudden hearing loss,PTA examination was performed to determine their recovery status,and they were divided into ineffective group and effective group according to prognosis.The characteristics of MMN latency and amplitude in the effective group and the ineffective group were observed and compared with the normal control group.Results The MMN waveform was elicited normally in 51 patients with sudden hearing loss and 26 cases in the normal group,of which 29 were in effective group and 22 were in ineffective group.There were significant statistical differences in MMN latency between the patients group and the normal group(P<0.05).Anova showed no significant difference in MMN latency between the invalid group and the effective group(P>0.05),and there was no significant difference in amplitude among the three groups(P>0.05).Conclusion The MMN latency of sudden hearing loss patients was signifanty shortened.There were no differences in MMN latency and amplitude between the ineffective group and the effective group.