输血相关性移植物抗宿主病的研究进展

Research Progress in Transfusion-Associated Graft-Versus-Host

输血相关性移植物抗宿主病(transfusion-associated graft-versus-host disease,TA-GVHD)是一种罕见且致命的输血并发症,由免疫反应引起,通常在输血后2~30 d内发生,发病率极低(0.01%~0.1%),但死亡率极高(≥90%),至今尚无有效的治疗方法。本文就TA-GVHD的发病机制、诊断、预防及治疗进行综述,为TA-GVHD的诊断和预防奠定基础。

Transfusion-associated graft-versus-host(TA-GVHD)is a rare but fatal complication of blood transfusion.It is caused by an immune response and usually occurs 2 to 30 days after blood transfusion.The incidence is extremely low(0.01%-0.1%),but the mortal⁃ity rate is extremely high(≥90%),and there is no effective treatment so far.This article reviews the pathogenesis,diagnosis,prevention and treatment of TA-GVHD,laying the foundation for the diagnosis and prevention of TA-GVHD.