摘要
Poor stability and dispersibility,as well as aggregation are considered as major challenges in clinical application of iron oxide nanoparticles(IONPs).Several studies have shown that the synthesis parameters and post-synthesis treatments e.g.,drying methods,have the capability to improve the particles'characteristics.Herein,we investigate the combined effect of synthesis and post-treatment parameters on the particle size,stability and magnetism of IONPs.Magnetite(Fe_(3)O_(4))NPs were prepared via co-precipitation and post-treated using different methods,i.e.(i)freeze dried at-53℃,0.133 mbar for 48 h(liquid nitrogen frozen(LFD)and freezer frozen(FFD)),(ii)vacuum oven dried(VOD)at 60℃for 24 h,and(iii)kept wet colloidal(WET),dispersed in deionized water.The Fe_(3)O_(4)NPs’chemical functional groups,size,shape,crystallinity,stability,aggregation,porosity,and magnetic properties were further analysed using different characterisation techniques.Analytical results showed that,while the WET sample had the best stability and significantly less aggregation at different temperatures,amongst post-treated Fe_(3)O_(4)NPs,LFD sample exhibited the best stability(up to 37℃),dispersion and smallest polydispersity index.Furthermore,all dried NPs had superparamagnetic characteristics,while,LFD Fe_(3)O_(4)NPs had better magnetic properties and stability than other drying methods.
