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坤泰胶囊联合芬吗通对卵巢早衰患者的临床疗效

The effect of Kuntai capsules combined with fenmutong on patients with premature ovarian failure
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摘要 目的:评估坤泰胶囊联合芬吗通对卵巢早衰患者的临床疗效,及对恢复或提升卵巢功能的作用。方法:选取本院2021年1月-2023年10月收治的82例卵巢早衰患者。按照随机分配法分成两组,观察组和对照组各41例。对照组的患者将接受芬吗通治疗,治疗周期为28 d/疗程。在治疗周期的前14 d,患者口服含2 mg雌二醇的砖红色药片,1片/次,1次/d;在治疗周期的15~28 d,患者口服含1 mg雌二醇和10 mg地屈孕酮的灰色药片,1片/次,1次/d。观察组在对照组的基础上联合坤泰胶囊治疗,4粒/次,餐后口服,3次/d,两组均治疗3个月。比较两组患者性激素水平与卵巢血流状况、卵巢彩超指标、血清中细胞因子及不良反应。结果:治疗前两组性激素水平比较差异无统计学意义(P>0.05);治疗后两组雌二醇水平均有所升高,促卵泡激素和促黄体生成素则下降(P<0.05);观察组治疗后雌二醇高于对照组,促卵泡激素和促黄体生成素则显著低于对照组,差异有统计学意义(P<0.05)。治疗前两组卵巢血流状况比较差异无统计学意义(P>0.05);治疗后两组收缩期峰值血流速度均升高,阻力指数和搏动指数则降低(P>0.05);观察组治疗后收缩期峰值血流速度明显高于对照组,阻力指数和搏动指数则低于对照组,差异有统计学意义(P<0.05)。治疗前两组卵巢彩超指标比较差异无统计学意义(P>0.05);治疗后两组子宫内膜厚度、窦卵泡数和卵巢体积均有所升高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前两组血清细胞因子水平比较差异无统计学意义(P>0.05);治疗后两组辅助性T细胞17低于治疗前,而调节性T细胞和转化生长因子-β1高于治疗前(P>0.05);观察组治疗后辅助性T细胞17低于对照组,而调节性T细胞和转化生长因子-β1则显著高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率少于对照组,差异有统计学意义(P<0.05)。结论:坤泰胶囊与芬吗通联合应用在治疗卵巢早衰患者中展现出了显著的效果,能够改善患者的临床症状,调节性激素水平,恢复卵巢功能,并具有较好的安全性和耐受性。这为卵巢早衰的治疗提供了新的有效方案。 Objective:To evaluate the clinical efficacy of Kuntai capsules combined with fenmotiong in the treatment of premature ovarian failure,and its role in restoring or improving ovarian function.Methods:82 patients with premature ovarian failure admitted to the Nanchang People's Hospital between January 2021 and October 2023 were selected.They were randomly divided into two groups,the observation group and the control group,with 41 patients each.Patients in the control group were treated with fenmotiong,with a treatment cycle of 28 days per course.In the first 14 days of the treatment cycle,the patient took brick red tablets containing 2 mg of estradiol orally,1 tablet/time,once a day.During the 15~28 d treatment period,the patients were given gray tablets containing 1 mg of estradiol and 10 mg of dydrogesterone orally,1 tablet/time,once a day.The observation group was treated with Kuntai capsules on the basis of the control group,4 capsules/time,taken orally after meals,3 times/day,and both groups were treated for 3 months.The levels of sex hormones,ovarian blood flow,ovarian color doppler ultrasound indices,serum cytokines,and adverse reactions were compared between the two groups.Results:There was no significant difference in sex hormone levels between the two groups before treatment(P>0.05).After treatment,the levels of estradiol in both groups increased,while those of follicle-stimulating and luteinizing hormones decreased(P<0.05).After treatment,the estradiol levels in the observation group were significantly higher than those in the control group,whereas the levels of follicle-stimulating hormone and luteinizing hormone were significantly lower than those in the control group(P<0.05).There was no significant difference in ovarian blood flow between the two groups before treatment(P>0.05).After treatment,the peak systolic blood flow velocity in both groups increased,whereas the resistance index and pulsatility index decreased(P>0.05).After treatment,the peak systolic blood flow velocity in the observation group was significantly higher than that in the control group,whereas the resistance index and pulsatility index were significantly lower in the observation group than in the control group(P<0.05).Before treatment,there was no significant difference in the indices of ovarian color Doppler ultrasound between the two groups(P>0.05).After treatment,the endometrial thickness,number of antral follicles,and ovarian volume of the two groups increased,and the observation group was significantly higher than that of the control group(P<0.05).There was no significant difference in the serum cytokine levels between the two groups before treatment(P>0.05).After treatment,the helper T cells 17 in the two groups were lower than before treatment,whereas the regulatory T cells and transforming growth factor-β1 were higher than before treatment(P>0.05).After treatment,the helper T cells 17 in the observation group were lower than those in the control group,while the regulatory T cells and transforming growth factor-β1 were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:The combined application of Kuntai Capsule and Fenmotiong in the treatment of patients with premature ovarian failure showed remarkable effects,which can improve the clinical symptoms of patients,regulate the level of sex hormones,restore ovarian function,and have good safety and tolerance.This study provides a new and effective method for the treatment of premature ovarian failure.
作者 王莉 袁超君 陈佳 Wang Li;Yuan Chaoun;Chen Jia(Nanchang People's Hospital,Jiangxi330000)
机构地区 南昌市人民医院
出处 《天津药学》 2024年第4期33-37,共5页 Tianjin Pharmacy
关键词 坤泰胶囊 芬吗通 卵巢早衰 联合应用 治疗效果 Kuntai capsules fenmatong premature ovarian failure joint application treatment effect
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