大定风珠联合西药治疗髓海不足型帕金森病临床观察

Efficacy observation of Dading Fengzhu decoction and western medicine on Parkinson's disease with syndrome of marrow sea insufficiency

目的:观察大定风珠联合多巴丝肼片和普拉克索片治疗帕金森病的临床疗效。方法:将64例帕金森病患者采用随机数字表法分为两组各32例。对照组予多巴丝肼片和普拉克索片治疗,治疗组在对照组基础上加用大定风珠,两组疗程均为12周。采用中医证候量化表、帕金森病综合评分量表(UPDRS)、PD生活质量评分(PDQ-39)进行疗效评价。结果:治疗组总有效率87.5%高于对照组的53.1%,差异有统计学意义(P﹤0.01);两组患者UPDRS、PDQ-39及中医证候量表评分较治疗前明显降低,差异具有统计学意义(P﹤0.05),且治疗组积分较对照组低(P﹤0.05)。结论:大定风珠联合普拉克索、多巴丝肼片可有效缓解帕金森病患者的临床症状,改善其生活质量,疗效较好。

Objective:To observe the clinical efficacy of Dading Fengzhu decoction and western medicine on Parkinson's disease(PD).Methods:64 cases of PD patients were randomly divided into two groups,32 cases in each group.The control group was treated with levodopa and benserazide tablets and pramipexole tablets,while the treatment group was treated plus with Dading Fengzhu decoction on the basis of control group.For both groups,the course of treatment was 12 weeks.The curative effect was evaluated by TCM syndrome quantization scale,Unified Parkinson's Disease Rating Scale(UPDRS)and Parkinson's disease questionnaire-39(PDQ-39).Results:The total effective rate of treatment group was 87.5%,which was higher than 53.1%of control group,and the difference was statistically significant(P﹤0.01).The scores of UPDRS,PDQ-39 and TCM syndrome quantization scale were significantly decreased compared with before treatment,and the difference was statistically significant(P﹤0.05),and the scores of treatment group were lower than those of control group(P﹤0.05).Conclusion:Dading Fengzhu decoction and levodopa and benserazide tablets and pramipexole tablets can effectively relieve the clinical symptoms of patients with Parkinson's disease,and improve their quality of life,and the clinical efficacy is better.