催化弱配位基团参与的C—H炔基化反应研究

Study on C--H Alkynylation Reaction Involving Weak Coordination Groups

炔烃是药物和天然产物结构中的一种非常重要的骨架,其炔基可以与多种化合物反应转化为其他官能团的产物,所以其合成一直是有机化学家研究的重点。近些年,C—H活化反应被广泛研究,可以直接被官能团化,而不需要事先进行活化。因此,用金属直接催化进行C—H炔化反应已成为一种非常有前景的合成炔烃的方法,以获得炔类化合物。文章旨在[RuCl_(2)(p-cymene)]_(2)催化剂的催化作用下,在导向基团硫代酰胺的导向下,使二茂铁环与炔基化试剂进行反应生成一种高产率的双炔基化的二茂铁硫代酰胺化合物。

Alkynes are very important skeletons in the structure of drugs and natural products.Their alkynyl can react with many compounds and convert into products of other functional groups,therefore,its synthesis has been the focus of organic chemists.In recent years,CH activation reaction has been extensively studied,which can be directly functionalized without prior activation.Therefore,C H acetylene reaction directly catalyzed by metal has become a very promising method for the synthesis of alkynes and obtaining acetylene compounds.The aim of this paper is to react ferrocene with acetylenylation reagent under the catalysis of【RuCl_(2)(p-cymene)】_(2),under the guidance of the guiding group thioamide to produce a high-yield diacetylated ferrocene thioamide compound.