运动干预对造血干细胞移植患者疲乏影响的Meta分析

Effects of exercise interventions on fatigue of hematopoietic stem cell transplantation patients:A Meta-analysis

目的评价运动干预对造血干细胞移植(HSCT)患者疲乏的影响。方法检索Cochrane library、PubMed、Web of Science、Embase、CINAHL、中国知网(CNKI)、万方(Wanfang Data)、维普(VIP)、中国生物医学文献数据库(CBM)中HSCT患者运动干预的随机对照试验,检索时限为建库至2024年2月。采用RevMan 5.3软件进行Meta分析。结果共纳入6篇文献,Meta分析结果显示,试验组与对照组的疲乏得分差异有统计学意义[SMD=-0.24,95%CI(-0.44,-0.03),P<0.001]。亚组分析,运动干预能够改善异基因HSCT患者的疲乏[SMD=-0.58,95%CI(-0.80,-0.35),P<0.001];贯穿整个移植期[SMD=-0.58,95%CI(-0.80,-0.35),P<0.001]、超过12周的运动干预[SMD=-0.53,95%CI(-0.78,-0.29),P<0.001]能减轻患者的疲乏。结论运动干预能够改善HSCT患者的疲乏,需注意运动的强度、时长及个体化。未来需要高质量、大样本、多人群的研究进一步验证其干预效果。

Objective To systematically evaluate the effect of exercise interventions on the fatigue for patients with Hematopoietic Stem Cell Transplantation(HSCT)through a meta-analy⁃sis.Methods Randomized controlled trials on exercise intervention in patients with HSCT were retrieved from Cochrane library,PubMed,Web of Science,Embase,CINAHL,CNKI,Wan⁃fang Data,VIP,and CBM databases from the establishment to February 2024;ReMan 5.3 soft⁃ware was used for meta-analysis.Results A total of six studies were included,and the results of meta-analysis showed a statistically significant difference in fatigue scores between the experimen⁃tal and control groups[SMD=-0.24,95%CI(-0.44,-0.03),P<0.001];subgroup analysis showed that exercise intervention improved fatigue in HSCT patients[SMD=-0.58,95%CI(-0.80,-0.35),P<0.001];exercise interventions throughout the transplant period[SMD=-0.58,95%CI(-0.80,-0.35),P<0.001],and duration longer than 12 weeks[SMD=-0.53,95%CI(-0.78,-0.29),P<0.001]can reduce fatigue.Conclusion Exercise interventions can effectively improve the fatigue of HSCT patients,and more attention should be paid to exercise in⁃tensity,duration and the individualized manner.Studies with high-quality,large-sample,multipopulation are needed to further verify its effect.