早期规律使用润肤剂在新生儿特应性皮炎防治中作用

The role of early regular use of emollients in the prevention and treatment of infantile atopic dermatitis

皮肤屏障功能受损在特应性皮炎(atopic dermatitis,AD)的发生中起重要作用。润肤剂可以通过增强皮肤屏障功能,减少经皮水分丢失,维持角质层的水合状态。特应性皮炎与食物过敏、过敏性鼻炎、过敏性哮喘有密切关系。早期有效预防AD发生的措施可以减少家庭及社会的经济负担。本文就AD与皮肤屏障及过敏性疾病之间的关系,以及润肤剂在预防AD的应用中进行综述,讨论新生儿早期规律使用润肤剂能否有效预防特应性皮炎的发生以及降低过敏性疾病的风险。

Impaired epidermal barrier function plays a pivotal role in the pathogenesis of atopic dermatitis(AD).Emollients can fortify the skin barrier,diminish transepidermal water loss,and maintain stratum corneum hydration.AD is closely associated with comorbidities such as food allergies,allergic rhinitis,and allergic asthma.Implementing effective preventive measures in the early stages of AD can alleviate the economic burden on families and society.This review explores the relationship between AD and skin barrier and allergic diseases,as well as the application of emollients in the prevention of AD,and discusses whether regular use of emollients in early neonates can effectively prevent the occurrence of atopic dermatitis and reduce the risk of allergic diseases.