肺上皮细胞昼夜节律紊乱在慢性阻塞性肺疾病中的作用

Dysregulated circadian rhythms in pulmonary epithelial cells in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(简称慢阻肺)已成为中国三大常见慢性病之一,但其发病机制尚未完全阐明,治疗手段也较为有限。肺上皮细胞在慢阻肺发病中起到至关重要的作用。吸烟导致的肺上皮细胞生物钟紊乱与慢阻肺发病的关系日益受到关注。本文就气道上皮细胞和肺泡上皮细胞昼夜节律调控紊乱在慢阻肺发病机制中的研究现状,以及潜在的药物治疗策略和未来研究方向作一评述,以期为慢阻肺发病机制研究及其临床治疗提供借鉴与参考。

Chronic obstructive pulmonary disease(COPD)ranks among China’s top three prevalent chronic diseases,with its pathogenesis still partially understood and therapeutic interventions limited.Pulmonary epithelial cells are central to development of COPD.Growing interest surrounds cigarette smoKing-induced disturbances of circadian rhythms in lung epithelial cell and their role in COPD initiation.This review comprehensively examined current research on circadian rhythm dysregulation in airway and alveolar epi⁃thelial cells concerning COPD pathogenesis,exploring potential pharmacotherapies and suggesting avenues for future study.