摘要
By rational modification of electronic and steric properties of pincer ligands,a Co/Fe dual catalyst system is developed for one-pot sequential Markovnikov alkyne hydrosilylation and stereoselective alkene isomerization.The protocol provides an atom-economical and efficient approach to trisubstituted(E)-alkenyl silanes from widely accessible terminal alkynes with high regio-and stereoselectivities under mild conditions.The utility of this reaction was demonstrated by gram-scale synthesis and derivatization of bioactive molecules.The radical clock and trapping experiments indicated that radical pathway might be operative in the alkene isomerization step.
基金
the National Key R&D Program of China(2021YFA1500100)
the National Natural Science Foundation of China(21825109,21821002,22072178,22293013)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0610000)
CAS Project for Young Scientists in Basic Research(YSBR-094)
Science and Technology Commission of Shanghai Municipality(23JC1404400)
CAS Youth Interdisciplinary Team(JCTD-2021-11).