摘要
A new,selective Ru(Ⅱ)-catalyzed alkynylation reaction of isoquinolones,quinazolones and phthalazinones with readily available bromoalkynes has been developed.This reaction enables the selective construction of a new C(sp^(2))-C(sp)bond through C-H activation and C-Br functionalization,and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone,quinazolone and phthalazinonederivatives with a wide substrate scope and highselectivity.
基金
supported by the Natural Science Foundation of Shandong Province(ZR2019BB011)
the Scientific Research Foundation of Qingdao University of Science&Technology(010029022).
