肠道菌群代谢物胆汁酸与银屑病的研究进展

Advances inmicrobial bile acid metabolites in human psoriasis

银屑病(psoriasis)是与免疫相关的、易复发的慢性炎症性皮肤病,目前还不能完全治愈。银屑病病因和发病机制复杂,炎症因子释放导致的免疫细胞失衡和功能紊乱是银屑病发病的关键。近年来,肠道菌群代谢物与炎症性疾病的研究越来越多,让人们对于肠道菌群代谢物的认识更加深入。胆汁酸(bile acid,BA)是在肠道菌群作用下生成的具有生物活性的代谢产物之一,具有调节免疫平衡、抑制炎症反应、维护内环境稳态等功能。现就BA与银屑病的关系以及相关作用机制作一概述,以期为银屑病的治疗提供新思路。

Psoriasis(PSO)is an immune-related,relapsing,chronic inflammatory skin disease that cannot be completely cured yet.The etiology and pathogenesis of psoriasis are so complex,among which the imbalance and dysfunction of immune cells caused by the release of inflammatory factors is the key to the development of the disease.Recently evidences from the increasing number of studies on inflammatory diseases have led to a deeper understanding of gut flora metabolites.One prime example is bile acid(BA),which has the functions of regulating immune balance,inhibiting inflammatory response,and maintaining the homeostasis of the internal environment.This review summarizes the relationship and related mechanisms of action between BA and psoriasis,with a view to providing new ideas for the treatment of psoriasis.