N6-甲基腺嘌呤甲基化修饰在风湿免疫性疾病发病中的潜在作用研究进展

Potential role of m6A RNA methylation in rheumatic immune diseases

查阅相关文献,从N6-甲基腺嘌呤(m6A)甲基转移酶、m6A去甲基化酶、m6A阅读蛋白3个方面对m6A进行概述,并从m6A RNA甲基化修饰与类风湿关节炎、骨关节炎及系统性红斑狼疮3个方面总结m6A甲基化修饰在风湿免疫性疾病发病中的作用。结果发现,m6A RNA甲基化修饰通过促进滑膜细胞的增生、纤维样改变及调节不同免疫细胞和骨细胞等多种途径,参与风湿免疫性疾病的发病过程。因此,进一步阐明m6A在风湿免疫性疾病中的潜在分子机制,可为探究这类疾病的发病机制提供新的视角,同时也为新药研发及中药干预这类疾病提供精确的靶点。

This paper provides an overview of the literature on m6A,focusing on N6-methyladenine(m6A)methyltransferase,m6A demethylase,and m6A reading protein.It delves into the specific role of m6A RNA methylation in the pathogenesis of rheumatoid arthritis,osteoarthritis,and systemic lupus erythematosus.Research has found that m6A RNA methylation is implicated in the pathogenesis of rheumatic immune diseases by promoting synovial cell proliferation,inducing fibroblast-like changes,and regulating various immune cells and bone cells.Therefore,gaining further insight into the potential molecular mechanisms of m6A in rheumatic immune diseases can offer new perspectives for exploring disease pathogenesis and identifying precise targets for developing new drugs as well as traditional Chinese medicine interventions.