不同免疫程序对肉鸽禽流感免疫效果的影响

The effect of different immunization procedures on the immune response of meat pigeons to avian influenza

本试验以鸽为对象,探讨不同免疫程序对其禽流感抗体水平的影响。试验分为5个试验组(Ⅰ~Ⅴ组)和1个空白对照组(Ⅵ组),于15日龄时检测各组母源抗体,抗体效价均值均低于4.0log2,60日龄时试验1至试验5组禽流感H5亚型抗体均值均为12log2,禽流感H7亚型抗体均值分别为6.6log2、7.8log2、9.0log2、9.6log2和7.4log2。试验结果表明,单次免疫剂量大的免疫效果较好,二次免疫效果比单次免疫效果更好;相同条件下禽流感疫苗与硫酸头孢喹肟混合注射,抗体水平会更高。

This experiment takes pigeons as the object to explore the influence of different immunization procedures on the level of their avian influenza antibody.The experiment is divided into 5 test groups(groupⅠ~Ⅴ)and 1 blank control group(groupⅥ).The maternal antibody of each group is detected at the age of 15 days,and the average antibody titer is lower than 4.0log2.At the age of 60 days,the average of avian influenza H5 subtype antibody in groupsⅠtoⅤis all 12log2,and the average of avian influenza H7 subtype antibody is 6.6log2,7.8log2,9.0log2,9.6log2 and 7.4log2 respectively.The experimental results show that the immunization effect with a large single immunization dose is better,and the immunization effect of the second immunization is better than that of the single immunization;under the same conditions,when the avian influenza vaccine is mixed with cefquinome sulfate for injection,the antibody level will be higher.