CACNA1C rs58619945基因型对双相情感障碍Ⅰ型患者注意网络皮质厚度的影响

CACNA1C rs58619945 genotype influences the cortical thickness of attention network among patients with BipolarⅠdisorder

目的探讨CACNA1C rs58619945基因型对双相情感障碍Ⅰ型(BD-Ⅰ)患者注意网络皮质厚度的影响。方法选取2013年8月至2019年8月在广州医科大学附属脑科医院门诊和住院部就诊的155例BD-Ⅰ患者与来自社区和大学招募的82名健康对照者(HC)为研究对象。对BD-Ⅰ患者和HC受试者进行CACNA1C rs58619945基因分型,并采用3.0 T磁共振成像系统进行扫描,获取警觉、定向和执行控制这3个亚注意网络的皮层厚度。采用一般线性模型(GLM)评估CACNA1C rs58619945基因型对注意网络皮质厚度的影响,同时采用重复性成套神经心理状态测验(RBANS)和剑桥神经心理自动化成套测试软件中快速视觉信息处理测试(CANTAB RVP)评估注意维度功能。本研究通过广州医科大学附属脑科医院医学伦理委员会的审查[伦理号:(2013)第(056)号]。结果与HC组相比,BD-Ⅰ组的双侧前额叶皮层、双侧后顶叶皮层和双侧颞上回皮层的厚度均减少(P<0.05)。CACNA1C基因型与诊断(HC vs.BD)之间在右前额叶皮层、右后顶叶皮层和右颞上回叶皮层厚度上均存在显著交互作用(P<0.05)。偏相关分析结果显示,CANTAB RVP和RBANS注意力指数与右前额叶皮层、右后顶叶皮层和右颞上回皮层厚度均呈显著正相关(P<0.05),且主要在BD-ⅠG等位基因携带者中。结论CACNA1C rs58619945 G等位基因与BD-Ⅰ患者的警觉和定向网络中的右前额叶皮层、右后顶叶皮层和右颞上回皮层的形态学变化存在相关性。

ObjectiveTo explore the impact of CACNA1C rs58619945 genotype on the cortical thickness of attentional networks in patients with Bipolar 1 disorder type(BD-Ⅰ).MethodsFrom August 2013 and August 2019,a total of 155 BD-Ⅰpatients were recruited from the outpatient and inpatient Departments of the Affiliated Brain Hospital of Guangzhou Medical University,along with 82 healthy controls(HC)from the community and university.Genotype for the CACNA1C rs58619945 locus was determined for all BD-I patients and HC subjects,followed by 3.0 T magnetic resonance imaging scans to measure the cortical thickness in the alert,orienting,and executive control subnetworks.General linear models(GLMs)were used to evaluate the impact of CACNA1C rs58619945 on the cortical thickness of attentional networks.Concurrently,attentional dimension functions were assessed using repeatable battery for the assessment of neuropsychological status(RBANS)and Cambridge neuropsychological test automated battery rapid visual information processing(CANTAB RVP)test.This study was approved by the Medical Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University(Ethics No.2023-056).ResultsCompared with the HC group,the BD-Ⅰpatients had shown reduced thickness in bilateral prefrontal cortex,bilateral posterior cingulate cortex,and bilateral superior temporal cortex(P<0.05).A significant interaction between the CACNA1C genotype and the cortical thickness(HC vs.BD)of right prefrontal cortex,right posterior parietal cortex and right superior temporal cortex was noted(P<0.05).Partial correlation analysis has demonstrated a significant correlation between CANTAB RVP and RBANS attention indices and cortical thickness in the right prefrontal cortex,right posterior cingulate cortex(P<0.05),and right superior temporal cortex predominantly among carriers of the BD-ⅠG allele.ConclusionThe G allele of CACNA1C rs58619945 is associated with cortical thickness of the right prefrontal cortex,right posterior cingulate cortex,and right superior temporal cortex in BD-Ⅰ,which are part of the alerting and orienting network.