老年多发性脑梗死患者血清CRP、Hcy、MMP-9水平与并发医院获得性肺炎的关系

Relationship of Serum Levels of CRP,Hcy,and MMP-9 with Concurrent Pneumonia in Elderly Patients with Multiple Cerebral Infarctions

【目的】探讨老年多发性脑梗死患者血清C反应蛋白(CRP)、同型半胱氨酸(Hcy)、基质金属蛋白-9(MMP-9)水平与并发医院获得性肺炎的关系。【方法】回顾性分析80例老年多发性脑梗死患者的临床资料,根据患者是否并发医院获得性肺炎分为并发组(n=18)和未并发组(n=62)。比较两组患者的一般资料及血清CRP、Hcy、MMP-9水平。采用受试者工作特征(ROC)曲线分析CRP、Hcy、MMP-9水平预测患者并发医院获得性肺炎的价值;采用多因素Logistic回归性分析明确患者并发医院获得性肺炎的危险因素。【结果】并发组年龄≥70岁、有肺部疾病病史的患者占比显著高于未并发组(P<0.05),CRP、Hcy、MMP-9水平显著高于未并发组(P<0.05);经ROC和Logistic分析显示,CRP、Hcy、MMP-9预测患者并发医院获得性肺炎的曲线下面积分别为0.834、0.850、0.752(P<0.05);年龄≥70岁、CRP≥21.725 mg/L、有肺部疾病病史、Hcy≥21.420μmol/L、MMP-9≥385.255 ng/mL是患者并发医院获得性肺炎的危险因素(P<0.05)。【结论】血清CRP、Hcy、MMP-9水平对老年多发性脑梗死患者并发医院获得性肺炎具有一定的预测价值。

【Objective】To explore the relationship of serum levels of C-reactive protein(CRP),homocysteine(Hcy),and matrix metalloproteinase-9(MMP-9)with the occurrence of concurrent pneumonia in elderly patients with multiple cerebral infarctions.【Methods】The clinical data of 80 elderly patients with multiple cerebral infarctions were retrospectively analyzed.The patients were divided into two groups based on whether they had hospital-acquired pneumonia:the concurrent pneumonia group(n=18)and the non-concurrent pneumonia group(n=62).General data and serum levels of CRP,Hcy,and MMP-9 were compared between the two groups.The value of CRP,Hcy,and MMP-9 levels in predicting concurrent pneumonia was analyzed using receiver operating characteristic(ROC)curves.Multivariate Logistic regression analysis was applied to identify risk factors for concurrent pneumonia.【Results】The proportion of patients aged≥70 years and those with a history of pulmonary disease was significantly higher in the concurrent pneumonia group than in the non-concurrent pneumonia group(P<0.05).The levels of CRP,Hcy,and MMP-9 were significantly higher in the concurrent pneumonia group compared to the non-concurrent pneumonia group(P<0.05).ROC and Logistic analysis showed that the area under the curve(AUC)values of CRP,Hcy,and MMP-9 in predicting concurrent pneumonia were 0.834,0.850,and 0.752,respectively(P<0.05).Age≥70 years,a history of pulmonary disease,CRP≥21.725 mg/L,Hcy≥21.420μmol/L,and MMP-9≥385.255 ng/mL were identified as risk factors for concurrent pneumonia(P<0.05).【Conclusion】Monitoring serum levels of CRP,Hcy,and MMP-9 has predictive value for concurrent pneumonia in elderly patients with multiple cerebral infarctions.