血小板聚集率及血液黏度预测急性心肌梗死PCI术后院内发生主要不良心血管事件的价值

The Value of Platelet Aggregation Rate and Blood Viscosity in Predicting Major Adverse Cardiovascular Events in Patients with Acute Myocardial Infarction after PCI Surgery

【目的】探讨血小板聚集率及血液黏度预测急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后院内发生主要不良心血管事件(MACE)的价值。【方法】选取2020年3月至2022年2月在本院行PCI术治疗的98例AMI患者,根据患者术后30 d内MACE发生情况将其分为发生组(n=16)和未发生组(n=82)。比较两组患者的临床资料、血小板聚集率、血液黏度,采用Logistic多因素回归分析PCI术后MACE发生的影响因素,采用受试者工作特征(ROC)曲线分析血小板聚集率、血液黏度对AMI患者PCI术后院内MACE发生风险的预测价值。【结果】AMI患者PCI术后院内MACE发生率为16.33%。发生组左室射血分数低于未发生组,左室收缩末容积、左室舒张末容积、血小板聚集率、血液黏度高于未发生组,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,血小板聚集率、血液黏度均为影响AMI患者PCI术后MACE发生的相关因素(P<0.05)。血`小板聚集率、血液黏度及两者联合预测AMI患者PCI术后院内MACE发生的灵敏度分别为68.75%、75.00%、68.75%,特异度分别为78.05%、73.17%、97.56%,AUC分别为0.721、0.748、0.887(P<0.05)。【结论】血小板聚集率、血液黏度两者联合对AMI患者PCI术后院内MACE发生的预测价值较高。

【Objective】To explore the value of platelet aggregation rate and blood viscosity in predicting major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).【Methods】Ninety eight patients with acute myocardial infarction(AMI)who underwent PCI treatment in our hospital from March 2020 to February 2022 were selected.They were divided into an occurrence group(n=16)and a non occurrence group(n=82)based on the occurrence of MACE within 30 days after surgery.Comparing the clinical data,platelet aggregation rate,and blood viscosity of two groups of patients,logistic multiple regression analysis was used to identify the influencing factors of MACE occurrence after PCI.Receiver operating characteristic(ROC)curves were used to analyze the predictive value of platelet aggregation rate and blood viscosity on the risk of MACE occurrence in AMI patients after PCI.【Results】The incidence of MACE in AMI patients after PCI is 16.33%.The left ventricular ejection fraction was lower in the occurrence group than in the non occurrence group,and the left ventricular end systolic volume,left ventricular end diastolic volume,platelet aggregation rate,and blood viscosity were higher in the occurrence group than in the non occurrence group,with statistically significant differences(P<0.05).Logistic multiple regression analysis showed that platelet aggregation rate and blood viscosity were both related factors affecting the occurrence of MACE in AMI patients after interventional surgery(P<0.05).The sensitivity,specificity,and AUC of platelet aggregation rate,blood viscosity,and their combined prediction of MACE after PCI were 68.75%,75.00%,and 68.75%,78.05%,73.17%,and 97.56%,respectively,and 0.721,0.748,and 0.887,respectively(P<0.05).【Conclusion】The combination of platelet aggregation rate and blood viscosity has a high predictive value for the occurrence of intracavitary MACE after AMI intervention.