非编码RNA调控细胞焦亡在肺癌中的研究进展

Research progress of non-coding RNA regulating pyroptosis in the pathogenesis of lung cancer

肺癌是我国最常见的癌症类型,其高发病率和高死亡率使其成为我国面临的重大公共卫生问题。细胞焦亡是一种新的程序性细胞死亡方式,越来越多的研究证实了非编码RNAs,如miRNA、lncRNA、circRNA,通过调节细胞焦亡在肺癌的发生发展、耐药和预后中起着重要作用。目前,关于非编码RNA调控细胞焦亡的研究主要集中在改善肺癌放化疗敏感性、肺癌预后及协同增效等方面。该文简要介绍了细胞焦亡,并综述了非编码RNA调节肺癌细胞焦亡的最新研究进展,以期揭示非编码RNA调控肺癌细胞焦亡的作用机制,从而以非编码RNA的角度为阐明细胞焦亡参与肺癌发生发展提供新的思路,进而为肺癌的治疗提供新靶点和新策略。

Lung cancer is the most common type of cancer in China,and its high morbidity and mortality make it a major public health problem in China.Pyroptosis is a new form of programmed cell death.More and more studies have confirmed that non-coding RNAs,such as miRNA,lncRNA and circRNA,play an important role in the occurrence and development,drug resistance and prognosis of lung cancer by regulating pyroptosis.At present,the research on the regulation of pyroptosis by non-coding RNA mainly focuses on improving the sensitivity of radiotherapy and chemotherapy,prognosis and synergy of lung cancer.This article briefly introduces pyroptosis,and reviews the latest research progress of non-coding RNA regulating pyroptosis in lung cancer cells,in order to reveal the mechanism of non-coding RNA regulating pyroptosis in lung cancer cells,so as to provide new ideas for elucidating the involvement of pyroptosis in the occurrence and development of lung cancer from the perspective of non-coding RNA,and then provide new targets and new strategies for the treatment of lung cancer.