肾小管上皮细胞脂肪酸代谢与脂质肾毒性的研究进展

Research progress on fatty acid metabolism and lipid nephrotoxicity in renal tubular epithelial cells*

脂质肾毒性假说将脂质代谢紊乱引入了肾脏病的研究领域。作为脂质的重要组分,脂肪酸在病理状态下可异位沉积于肾脏各类细胞,参与急性肾损伤(AKI)和慢性肾脏病(CKD)发生和进展。肾小管上皮细胞(TEC)脂肪酸异常代谢的机制及其功能改变与肾损伤紧密关联。该文通过总结TEC脂肪酸代谢与AKI、CKD的关系,阐述了脂肪酸代谢紊乱导致TEC损伤的具体机制,并探讨了基于调节脂肪酸代谢紊乱改善肾脏损伤的治疗策略。

The“lipid nephrotoxicity”hypothesis introduces the lipid metabolism disorders into the field of kidney disease research.Fatty acids as important components of lipids can be ectopic deposition in various cells of the kidney in pathological status,and are involved in the occurrence and progression of acute kidney injury(AKI)and chronic kidney disease(CKD).The mechanism of abnormal fatty acid metabolism in tubular epithelial cells(TEC)and its function change are closely associated with kidney injury.This article summarized the relationship between fatty acid metabolism in TEC with AKI and CKD,elaborated the specific mechanism of fatty acid metabolism disorders leading to TEC injury,and discussed the treatment strategies based on regulating fatty acid metabolism disorders to improve kidney injury.